Technology Process of methyl 3-amino-6-(4-fluorophenyl)-5-(trifluoromethyl)picolinate
There total 5 articles about methyl 3-amino-6-(4-fluorophenyl)-5-(trifluoromethyl)picolinate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate;
In
tetrahydrofuran;
at 160 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutylammomium bromide / toluene / 9 h / Reflux
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h
2.2: 24 h / Reflux
2.3: 84 h / Reflux
3.1: sulfuric acid; bromine / water; acetic acid / 18 h / 20 °C
4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran / 0.25 h / 160 °C / Inert atmosphere; Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; bromine; caesium carbonate;
In
tetrahydrofuran; water; acetic acid; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h
1.2: 24 h / Reflux
1.3: 84 h / Reflux
2.1: sulfuric acid; bromine / water; acetic acid / 18 h / 20 °C
3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / tetrahydrofuran / 0.25 h / 160 °C / Inert atmosphere; Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; bromine; caesium carbonate;
In
tetrahydrofuran; water; acetic acid; ethyl acetate;