Technology Process of 3,5-bis(2,5-bis(2-pyridyl)pyridin-4-ylethynyl)benzoic acid
There total 7 articles about 3,5-bis(2,5-bis(2-pyridyl)pyridin-4-ylethynyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / tetrahydrofuran / 10 h / Reflux
2: ammonium acetate / ethanol / 24 h / Reflux
3: phosphorus pentabromide; phosphorus(V) oxybromide / 12 h / 100 °C
4: triethylamine; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; triphenylphosphine / 48 h / 70 °C / Inert atmosphere
5: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; ammonium acetate; phosphorus pentabromide; sodium hydride; triethylamine; triphenylphosphine; lithium hydroxide; phosphorus(V) oxybromide;
In
tetrahydrofuran; methanol; ethanol; water;
DOI:10.2478/s11696-012-0196-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h
2: triethylamine; tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; triphenylphosphine / 48 h / 70 °C / Inert atmosphere
3: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; triphenylphosphine; lithium hydroxide;
In
tetrahydrofuran; methanol; water;
DOI:10.2478/s11696-012-0196-5