1-BROMO-8-FLUORONAPHTHALENE

Base Information

• Chemical Name: 1-BROMO-8-FLUORONAPHTHALENE
• CAS No.: 33718-15-9
• Molecular Formula: C10H6 Br F
• Molecular Weight: 225.06
• Hs Code.: 2903999090
• Mol file: 33718-15-9.mol

Synonyms:8-Bromo-1-fluoronaphthalene

Chemical Property of 1-BROMO-8-FLUORONAPHTHALENE

Chemical Property:

• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.638
• Boiling Point: 286.6°C at 760 mmHg
• Flash Point: 130.8°C
• PSA: 0.00000
• Density: 1.563g/cm³
• LogP: 3.74140

Purity/Quality:

98%min ^*data from raw suppliers

1-Bromo-8-fluoronaphthalene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-8-FLUORONAPHTHALENE

There total 3 articles about 1-BROMO-8-FLUORONAPHTHALENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-amino-8-bromonaphthalene (62456-34-2) → 1-bromo-8-fluoronaphthalene (33718-15-9)

Guidance literature:

1-amino-8-bromonaphthalene; With tetrafluoroboric acid; sodium tetrafluoroborate; sodium nitrite; In tetrahydrofuran; at 0 - 20 ℃;

In chlorobenzene; for 3h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2007.05.156

Reference yield:

8-bromonaphthalene-1-carboxylic acid (1729-99-3) → 1-bromo-8-fluoronaphthalene (33718-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 96 percent / H₂SO₄; NaN₃ / CHCl₃ / 45 °C

2.1: NaNO₂; HBF₄; NaBF₄ / tetrahydrofuran / 0 - 20 °C

2.2: 69 percent / chlorobenzene / 3 h / Heating

With tetrafluoroboric acid; sodium tetrafluoroborate; sodium azide; sulfuric acid; sodium nitrite; In tetrahydrofuran; chloroform; 1.1: Currtius rearrangement;

DOI:10.1016/j.tetlet.2007.05.156

Reference yield:

→ 1-bromo-8-fluoronaphthalene (33718-15-9)

Guidance literature:

upstream raw materials:

1-amino-8-bromonaphthalene

8-bromonaphthalene-1-carboxylic acid

Downstream raw materials:

1-Cyan-8-fluornaphthalin

7-methylfluoranthene

benzo[b]naphtho[1,8-de]pyran

1-formyl-8-fluoronaphthalene

Refernces

• 1、 -. "Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.