4-phenyl-3-tert-butoxycarbonylamino-1-butene

Base Information

• Chemical Name: 4-phenyl-3-tert-butoxycarbonylamino-1-butene
• CAS No.: 103127-52-2
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 103127-52-2.mol

Synonyms:4-phenyl-3-tert-butoxycarbonylamino-1-butene

Chemical Property of 4-phenyl-3-tert-butoxycarbonylamino-1-butene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-phenyl-3-tert-butoxycarbonylamino-1-butene

There total 37 articles about 4-phenyl-3-tert-butoxycarbonylamino-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

di-tert-butyl dicarbonate (24424-99-5) + (S)-3-acetylamino-4-phenyl-1-butene (220035-13-2) → ((S)-1-benzylallyl)carbamic acid tert-butyl ester (103127-52-2,107202-43-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 4h; under 760.051 Torr; Concentration;

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-1-phenylbut-3-en-2-amine (126410-30-8) → ((S)-1-benzylallyl)carbamic acid tert-butyl ester (103127-52-2,107202-43-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-amino-1-phenyl-but-3-ene hydrochloride → ((S)-1-benzylallyl)carbamic acid tert-butyl ester (103127-52-2,107202-43-7)

Guidance literature:

With sodium hydrogencarbonate; In water; isopropyl alcohol; at 20 ℃; for 48h;

DOI:10.1021/ml4004952

upstream raw materials:

di-tert-butyl dicarbonate

(S)-1-phenylbut-3-en-2-amine

N-tert-butoxycarbonyl-L-phenylalanine

Methyltriphenylphosphonium bromide

Downstream raw materials:

((1S,2R)-1-benzyl-2,3-dihydroxypropyl)carbamic acid tert-butyl ester

(2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol

(5S,1'S)-3-phenylmethyl-5-(1'-amino-2'-phenylethyl)-2-isoxazoline p-toluenesulfonate

(1S)-1-(2-oxiranyl)-2-phenyl-N-(trifluoromethyl)ethanamine

Refernces

• 1、 Lebel, Helene,Ladjel, Chehla. "Reductive one-carbon homologation of aldehydes and ketones". . p. 10159 - 10161. Retrieved 2005.
• 2、 Garro-Helion, Florence,Guibe, Francois. "New potential access to ethylenic pseudodipeptides through catalytic alkene metathesis". . p. 641 - 642. Retrieved 1996.
• 3、 Janssen, Antonius P.A.,Van Hengst, Jacob M.A.,Béquignon, Olivier J.M.,Deng, Hui,Van Westen, Gerard J.P.,Van Der Stelt, Mario. "Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors". supporting information. p. 7910 - 7922. Retrieved 2019/10/11.
• 4、 -. "A method of preparing intermediates of luck sha neiwei". Paragraph 0045; 0050; 0057; 0064. . Retrieved 2018/03/26.