Ethyl 1-naphthoylformate

Base Information

• Chemical Name: Ethyl 1-naphthoylformate
• CAS No.: 33656-65-4
• Molecular Formula: C14H12 O3
• Molecular Weight: 228.247
• Hs Code.: 2918300090
• DSSTox Substance ID: DTXSID50371373
• Nikkaji Number: J1.182.581H
• Wikidata: Q82158682
• Mol file: 33656-65-4.mol

Synonyms:Ethyl 1-naphthoylformate;33656-65-4;ethyl 2-(naphthalen-1-yl)-2-oxoacetate;ethyl 2-naphthalen-1-yl-2-oxoacetate;MFCD01319637;SCHEMBL697232;DTXSID50371373;ethyl (naphth-1-yl)(oxo)acetate;1-Naphthyloxoacetic acid ethyl ester;ethyl alpha-oxo-1-naphthaleneacetate;Ethyl (naphthalen-1-yl)(oxo)acetate;AKOS009157814;PS-7749;Ethyl 2-(1-naphthyl)glyoxylate, tech.;CS-0320334;FT-0625845;ethyl 2-(1-naphthyl)-2-oxoacetate, AldrichCPR

Chemical Property of Ethyl 1-naphthoylformate

Chemical Property:

• Vapor Pressure: 1.5E-05mmHg at 25°C
• Melting Point: 79-82 °C
• Refractive Index: 1.595
• Boiling Point: 366.1°Cat760mmHg
• Flash Point: 171.5°C
• PSA: 43.37000
• Density: 1.191g/cm³
• LogP: 2.58560
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 298

Purity/Quality:

97% ^*data from raw suppliers

Ethyl (naphth-1-yl)(oxo)acetate, tech 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(=O)C1=CC=CC2=CC=CC=C21

Technology Process of Ethyl 1-naphthoylformate

There total 14 articles about Ethyl 1-naphthoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(1-naphthyl)-2-diazoacetic acid ethyl ester (1398178-90-9) → ethyl 2-(1-naphthyl)-2-oxoacetate (33656-65-4)

Guidance literature:

With tris(pentafluorophenyl)borate; dimethyl sulfoxide; at 90 ℃; for 3h; Inert atmosphere;

DOI:10.1002/adsc.202101336

Reference yield: 77.0%

ethanol (64-17-5) + 3-dimethylamino-1-(naphthalene-1-yl)-prop-2-en-1-one → ethyl 2-(1-naphthyl)-2-oxoacetate (33656-65-4)

Guidance literature:

With acetic acid; Rose Bengal lactone; at 20 ℃; for 24h; chemoselective reaction; Molecular sieve; Photolysis;

DOI:10.1039/c9gc01357a

Reference yield: 62.0%

ethanol (64-17-5) + 2-(naphthalen-1-carbonyl)acetonitrile (39528-57-9) → ethyl 2-(1-naphthyl)-2-oxoacetate (33656-65-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; for 0.5h; Reflux;

DOI:10.1016/j.tetlet.2015.04.075

upstream raw materials:

ethyl 2-(1-naphthyl)acetate

naphthalene

Ethyl oxalyl chloride

oxalic acid diethyl ester

Downstream raw materials:

naphth-1-yl acetic acid

C₂₁H₁₉NO₄S

C₂₇H₂₇NO₆S

C₂₇H₂₇NO₆S

Refernces

• 1、 Wu, Xiao-Yang,Gao, Wen-Xia,Zhou, Yun-Bing,Liu, Miao-Chang,Wu, Hua-Yue. "Tris(pentafluorophenyl)borane-Catalyzed Oxygen Insertion Reaction of α-Diazoesters (α-Diazoamides) with Dimethyl Sulfoxide". supporting information. p. 750 - 754. Retrieved 2022/01/19.
• 2、 -. "Preparation method of alpha-naphthylacetic acid". Paragraph 0009; 0021; 0025. . Retrieved 2020/08/22.