C₁₂H₁₁BrN₂O₃S₂

Base Information

• Chemical Name: C₁₂H₁₁BrN₂O₃S₂
• CAS No.: 1448723-46-3
• Molecular Formula: C₁₂H₁₁BrN₂O₃S₂
• Molecular Weight: 375.267
• Mol file: 1448723-46-3.mol

Synonyms:C₁₂H₁₁BrN₂O₃S₂

Chemical Property of C₁₂H₁₁BrN₂O₃S₂

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of C₁₂H₁₁BrN₂O₃S₂

There total 2 articles about C₁₂H₁₁BrN₂O₃S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H19BrN2O5S2 (1448723-45-2) → C12H11BrN2O3S2 (1448723-46-3)

Guidance literature:

With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 0 - 20 ℃;

DOI:10.1039/c2sc22045h

Reference yield:

5-bromothiophene-2-carboxylic acid (7311-63-9) + tert-butyl 2-tosylhydrazine-1-carboxylate (260788-12-3) → C12H11BrN2O3S2 (1448723-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

2: chloro-trimethyl-silane; sodium iodide / acetonitrile / 0 - 20 °C

With dmap; chloro-trimethyl-silane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In dichloromethane; acetonitrile;

DOI:10.1039/c2sc22045h

Reference yield: 93.0%

C12H11BrN2O3S2 (1448723-46-3) → 5-bromo-2-thiophencarboxaldehyde (4701-17-1)

Guidance literature:

C₁₂H₁₁BrN₂O₃S₂; With 1H-imidazole; 1-(Trimethylsilyl)imidazole; In toluene; at 55 ℃;

With citric acid; In methanol; at 20 ℃;

DOI:10.1039/c2sc22045h

upstream raw materials:

5-bromothiophene-2-carboxylic acid

tert-butyl 2-tosylhydrazine-1-carboxylate

C₁₇H₁₉BrN₂O₅S₂

Downstream raw materials:

5-bromo-2-thiophencarboxaldehyde

Refernces