(1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene

Base Information

• Chemical Name: (1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene
• CAS No.: 1018479-86-1
• Molecular Formula: C₃₀H₄₈O₃Si
• Molecular Weight: 484.795
• Mol file: 1018479-86-1.mol

Synonyms:(1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene

Chemical Property of (1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene

There total 1 articles about (1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1S,8R,4aR)-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthol (1018479-94-1) + p-methoxybenzyl chloride (824-94-2) → (1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene (1018479-86-1)

Guidance literature:

(1S,8R,4aR)-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.416667h; Inert atmosphere;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; for 3h; Inert atmosphere;

DOI:10.1021/ol800101v

Reference yield:

(1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene (1018479-86-1) → {(1S,8S,4aS)-5-(hydroxymethyl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphth-2-yl}methan-1-ol (1018479-95-2)

Guidance literature:

(1S,8R,4aR)-1-[(4-methoxyphenyl)methoxy]-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthalene; With borane-THF; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; for 6h; Inert atmosphere;

DOI:10.1021/ol800101v

upstream raw materials:

(1S,8R,4aR)-8,4a-dimethyl-4,7-dimethylene-8-[2-(tert-butyldimethylsilanyloxy)ethyl]-1,2,3,5,6,8,4a,8a-octahydronaphthol

p-methoxybenzyl chloride

Downstream raw materials:

{(1S,8S,4aS)-5-(hydroxymethyl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphth-2-yl}methan-1-ol

Refernces