ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE

Base Information

• Chemical Name: ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE
• CAS No.: 395-00-6
• Molecular Formula: C8H5 Cl F2
• Molecular Weight: 174.578
• Mol file: 395-00-6.mol

Synonyms:Styrene, b-chloro-a,b-difluoro- (6CI,7CI,8CI);1-Chloro-1,2-difluoro-2-phenylethene; a,b-Difluoro-b-chlorostyrene;b-Chloro-a,b-difluorostyrene

Chemical Property of ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE

Chemical Property:

• Boiling Point: 72-73°C 20mm
• PSA: 0.00000
• LogP: 3.49050

Purity/Quality:

98%min ^*data from raw suppliers

[(E)-2-CHLORO-1,2-DIFLUOROETHENYL]BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

Technology Process of ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE

There total 5 articles about ALPHA,BETA-DIFLUORO-BETA-CHLOROSTYRENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-2-chloro-1,2-difluoro-1-iodo-ethene (14006-62-3) + phenylboronic acid (98-80-6) → (E/Z)-1-chloro-1,2-difluoro-2-phenylethene (395-00-6)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 2h; stereospecific reaction; Inert atmosphere;

DOI:10.1016/j.jfluchem.2016.01.018

Reference yield:

Chlorotrifluoroethylene (79-38-9,9036-80-0) + phenylmagnesium bromide → (E/Z)-1-chloro-1,2-difluoro-2-phenylethene (395-00-6)

Guidance literature:

In tetrahydrofuran;

Reference yield:

phenyl copper (3220-49-3) + α,β-difluoro-β-chlorovinyllithium (62269-26-5) → biphenyl (92-52-4,1594-86-1) + (E/Z)-1-chloro-1,2-difluoro-2-phenylethene (395-00-6)

Guidance literature:

With iodine; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) ether, THF, hexane, -70 to -65 deg C, 2 h; 2.) N-methylpyrrolidone, 120 deg C, 8 h;

upstream raw materials:

Chlorotrifluoroethylene

phenyllithium

phenyl copper

α,β-difluoro-β-chlorovinyllithium

Downstream raw materials:

Z-1-fluoro-2-chloro-1,2-diphenylethylene

trans-1,2-difluoro-1,2-diphenylethylene

4'-trifluoromethyl-α,β-difluorochalcone

4'-chloro-α,β-difluorochalcone

Refernces

• 1、 Kremlev, M. M.,Moklyachuk, L. I.,Fialkov, Yu. A.,Yagupol'skii, L. M.. "LITHIATION OF 1,2-DIFLUORODICHLOROETHENE AND 1,4-DICHLOROPERFLUOROBUTADIENE". . p. 814 - 817. Retrieved 2007/10/02.