2-fluoro-9H-carbazole

Base Information

• Chemical Name: 2-fluoro-9H-carbazole
• CAS No.: 391-53-7
• Molecular Formula: C12H8 F N
• Molecular Weight: 185.201
• Hs Code.: 2933990090
• European Community (EC) Number: 835-323-3
• DSSTox Substance ID: DTXSID90473486
• Nikkaji Number: J2.197.186C
• Mol file: 391-53-7.mol

Synonyms:2-fluoro-9H-carbazole;391-53-7;C12H8FN;2fluorocarbazole;7-fluoro-carbazole;SCHEMBL6756610;2-Fluoro-9H-carbazole, 99%;DTXSID90473486;RQGSXFCTBTUNRR-UHFFFAOYSA-N;MFCD09033508;AKOS006329634;AS-76653;CS-0378228;F1182;T72418

Chemical Property of 2-fluoro-9H-carbazole

Chemical Property:

• Melting Point: 224.0 to 228.0 °C
• Boiling Point: 359.2±15.0 °C(Predicted)
• PKA: 16.27±0.30(Predicted)
• PSA: 15.79000
• Density: 1.320±0.06 g/cm3(Predicted)
• LogP: 3.46020
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 185.064077422
• Heavy Atom Count: 14
• Complexity: 218

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-9H-carbazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=C(C=C3)F

Technology Process of 2-fluoro-9H-carbazole

There total 22 articles about 2-fluoro-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

4-fluoro-2-nitro-1,1′-biphenyl (390-06-7) → 2-fluoro-9H-carbazole (391-53-7)

Guidance literature:

With iron(II)chloride; iron; In 1,2-dichloro-benzene; at 80 ℃; for 10h; Temperature; Reagent/catalyst; Solvent;

Reference yield: 83.0%

4’-fluoro-[1,1’-biphenyl]-2,2’-iodonium triflate (1600505-70-1) → 2-fluoro-9H-carbazole (391-53-7)

Guidance literature:

With sodium azide; copper(I) thiophene-2-carboxylate; sodium hydrogencarbonate; triphenylphosphine; In N,N-dimethyl acetamide; at 100 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b03564

Reference yield: 83.0%

2-azido-4'-fluoro-1,1'-biphenyl (1140969-86-3) → 2-fluoro-9H-carbazole (391-53-7)

Guidance literature:

With dirhodium(II) tetrakis(perfluorobutyrate); In toluene; at 40 ℃; Inert atmosphere;

DOI:10.1021/ol901317j

upstream raw materials:

7-fluoro-1,2,3,4-tetrahydro-carbazole

chloranil

1-phenyl-6-fluoro-1H-benzo[d][1,2,3]triazole

4-fluoro-2-nitro-1,1′-biphenyl

Refernces

• 1、 Yang, Lizheng,Zhang, Yipin,Zou, Xiaodong,Lu, Hongjian,Li, Guigen. "Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles". supporting information. p. 1362 - 1366. Retrieved 2018/03/26.
• 2、 -. "Preparation of 2 - substituted oxazole compounds". Paragraph 0029; 0030. . Retrieved 2018/02/28.