N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide

Base Information

• Chemical Name: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide
• CAS No.: 1420403-40-2
• Molecular Formula: C₂₄H₂₄ClF₂N₅O₃
• Molecular Weight: 503.936
• Mol file: 1420403-40-2.mol

Synonyms:N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide

Chemical Property of N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide

There total 4 articles about N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-fluoroacrylic acid (430-99-9) + (3-CHLORO-4-FLUOROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE (267243-68-5) → N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide (1420403-40-2)

Guidance literature:

2-fluoroacrylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2.5h; Cooling with ice;

(3-CHLORO-4-FLUOROPHENYL)-[7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL]-AMINE; With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine (162012-67-1) → N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide (1420403-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.5 h / 0 - 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.5 h / 20 °C / Cooling with ice

3.2: 0 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; nickel(II) chloride hexahydrate; potassium tert-butylate; N,N-dimethyl-formamide; In methanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

3-morpholin-4-ylpropan-1-ol (4441-30-9) → N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)-2-fluoroacrylamide (1420403-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / dichloromethane; methanol / 0.5 h / 0 - 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2.5 h / 20 °C / Cooling with ice

3.2: 0 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; nickel(II) chloride hexahydrate; potassium tert-butylate; N,N-dimethyl-formamide; In methanol; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

3-morpholin-4-ylpropan-1-ol

(3-chloro-4-fluorophenyl)-[7-(3-morpholino-4-yl-propoxy)-6-nitroquinazolin-4-yl]-amine

2-fluoroacrylic acid

Refernces