N-methylpiperidine-4-yl-2-cyclohexyl-2-hydroxy-2- phenylacetate

Base Information

• Chemical Name: N-methylpiperidine-4-yl-2-cyclohexyl-2-hydroxy-2- phenylacetate
• CAS No.: 33445-17-9
• Molecular Formula: C₂₀H₂₉NO₃
• Molecular Weight: 331.455
• Mol file: 33445-17-9.mol

Synonyms:Cyclohexaneglycolicacid, a-phenyl-, 1-methyl-4-piperidinylester (8CI); Cyclohexaneglycolic acid, a-phenyl-, 1-methylpiperid-4-yl ester (6CI);4-Piperidinol, 1-methyl-, a-phenylcyclohexaneglycolate (ester);N-Methyl-piperidin-4-yl-2-cyclohexyl-2-hydroxy-2-phenylacetate

Chemical Property of N-methylpiperidine-4-yl-2-cyclohexyl-2-hydroxy-2- phenylacetate

Chemical Property:

• Vapor Pressure: 2.33E-09mmHg at 25°C
• Refractive Index: 1.566
• Boiling Point: 462.7°Cat760mmHg
• Flash Point: 233.6°C
• PSA: 49.77000
• Density: 1.14g/cm³
• LogP: 3.02980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-methylpiperidine-4-yl-2-cyclohexyl-2-hydroxy-2- phenylacetate

There total 5 articles about N-methylpiperidine-4-yl-2-cyclohexyl-2-hydroxy-2- phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

N-methyl-4-hydroxypiperidine (106-52-5) + methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate (10399-13-0) → cyclohexyl-hydroxy-phenyl-acetic acid-(1-methyl-[4]piperidyl ester) (33445-17-9,71579-76-5)

Guidance literature:

With sodium methylate; In n-heptane; for 15h; Heating;

DOI:10.1248/cpb.46.231

Reference yield:

Benzilic acid (76-93-7) → cyclohexyl-hydroxy-phenyl-acetic acid-(1-methyl-[4]piperidyl ester) (33445-17-9,71579-76-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂, glacial AcOH / PtO₂ / 28 h / 80 °C / 3102.9 Torr

2: NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

3: 25 percent / NaOMe / heptane / 15 h / Heating

With hydrogen; sodium methylate; sodium hydrogencarbonate; acetic acid; platinum(IV) oxide; In n-heptane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.231

Reference yield:

N-methyl-4-hydroxypiperidine (106-52-5) → cyclohexyl-hydroxy-phenyl-acetic acid-(1-methyl-[4]piperidyl ester) (33445-17-9,71579-76-5)

Guidance literature:

With sodium; Erhitzen des Reaktionsloesung mit (+-)-Cyclohexyl-hydroxy-phenyl-essigsaeure-aethylester auf 125grad bis 140grad/25-35 Torr;

DOI:10.1021/ja01596a040

upstream raw materials:

N-methyl-4-hydroxypiperidine

methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Benzilic acid

cyclohexylmandelic acid

Refernces