Technology Process of methyl (3R,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate
There total 6 articles about methyl (3R,4S)-5-cyclohexyl-3-hydroxy-4-(isopropoxycarbonyl)aminopentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / thionyl chloride
2: 91 percent / triethylamine
3: 98 percent / sodium borohydride, lithium chloride / tetrahydrofuran; ethanol
4: 100 percent / H2 / Rh-Al2O3 / acetic acid; methanol / 5 h / 3040 Torr / Ambient temperature
5: 78 percent / sulfur trioxide pyridine, triethylamine, dimethylsulfoxide / toluene / 0.33 h / Ambient temperature
6: TiCl4, molecular sieves / CH2Cl2 / 1 h / -78 °C
With
sodium tetrahydroborate; thionyl chloride; molecular sieve; hydrogen; sulfur trioxide pyridine complex; titanium tetrachloride; dimethyl sulfoxide; triethylamine; lithium chloride;
rhodium on alumina;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1248/cpb.39.2425
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / sodium borohydride, lithium chloride / tetrahydrofuran; ethanol
2: 100 percent / H2 / Rh-Al2O3 / acetic acid; methanol / 5 h / 3040 Torr / Ambient temperature
3: 78 percent / sulfur trioxide pyridine, triethylamine, dimethylsulfoxide / toluene / 0.33 h / Ambient temperature
4: TiCl4, molecular sieves / CH2Cl2 / 1 h / -78 °C
With
sodium tetrahydroborate; molecular sieve; hydrogen; sulfur trioxide pyridine complex; titanium tetrachloride; dimethyl sulfoxide; triethylamine; lithium chloride;
rhodium on alumina;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; toluene;
DOI:10.1248/cpb.39.2425
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / H2 / Rh-Al2O3 / acetic acid; methanol / 5 h / 3040 Torr / Ambient temperature
2: 78 percent / sulfur trioxide pyridine, triethylamine, dimethylsulfoxide / toluene / 0.33 h / Ambient temperature
3: TiCl4, molecular sieves / CH2Cl2 / 1 h / -78 °C
With
molecular sieve; hydrogen; sulfur trioxide pyridine complex; titanium tetrachloride; dimethyl sulfoxide; triethylamine;
rhodium on alumina;
In
methanol; dichloromethane; acetic acid; toluene;
DOI:10.1248/cpb.39.2425
