3-(2,5-dimethylphenyl)propanoic acid chloride

Base Information

• Chemical Name: 3-(2,5-dimethylphenyl)propanoic acid chloride
• CAS No.: 859966-58-8
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.677
• Mol file: 859966-58-8.mol

Synonyms:3-(2,5-dimethylphenyl)propanoic acid chloride

Chemical Property of 3-(2,5-dimethylphenyl)propanoic acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2,5-dimethylphenyl)propanoic acid chloride

There total 4 articles about 3-(2,5-dimethylphenyl)propanoic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

para-xylene (106-42-3) + 2-chloropropionyl chloride (625-36-5) → 3-(2,5-dimethylphenyl)propanoic acid chloride (859966-58-8)

Guidance literature:

With aluminium trichloride; In carbon disulfide; at 20 ℃; for 3h;

DOI:10.1021/ja003708m

Reference yield:

3-(2,5-dimethylphenyl)propanoic acid (25173-75-5) → 3-(2,5-dimethylphenyl)propanoic acid chloride (859966-58-8)

Guidance literature:

With thionyl chloride; benzene;

DOI:10.1002/hlca.19410240166

Reference yield:

2,5-dimethylbenzyl chloride (824-45-3) → 3-(2,5-dimethylphenyl)propanoic acid chloride (859966-58-8)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene / Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge und Erhitzen der erhaltenen <2.5-Dimethyl-benzyl>-malonsaeure

2: benzene; thionyl chloride

With thionyl chloride; xylene; benzene;

DOI:10.1002/hlca.19410240166

upstream raw materials:

3-(2,5-dimethylphenyl)propanoic acid

para-xylene

2-chloropropionyl chloride

2,5-dimethylbenzyl chloride

Downstream raw materials:

4,7-dimethylindane

4,7-dimethyl-indan-1-one

Refernces

• 1、 Chen, Junjie,Deady, Leslie W.,Desneves, Jose,Kaye, Anthony J.,Finlay, Graeme J.,Baguley, Bruce C.,Denny, William A.. "Synthesis of substituted indeno[1,2-b]quinoline-6-carboxamides, [1]benzothieno[3,2-b]quinoline-4-carboxamides and 10H-quindoline-4-carboxamides: Evaluation of structure-activity relationships for cytotoxicity". . p. 2461 - 2466. Retrieved 2007/10/03.