1-Chloroisoquinoline-7-carbaldehyde

Base Information

• Chemical Name: 1-Chloroisoquinoline-7-carbaldehyde
• CAS No.: 223671-53-2
• Molecular Formula: C₁₀H₆ClNO
• Molecular Weight: 191.617
• Hs Code.: 2933499090
• Mol file: 223671-53-2.mol

Synonyms:1-Chloroisoquinoline-7-carbaldehyde;

Chemical Property of 1-Chloroisoquinoline-7-carbaldehyde

Chemical Property:

• Vapor Pressure: 1.28E-05mmHg at 25°C
• Refractive Index: 1.692
• Boiling Point: 368.4 °C at 760 mmHg
• Flash Point: 176.6 °C
• PSA: 29.96000
• Density: 1.365 g/cm³
• LogP: 2.70070
• Storage Temp.: 2-8°C

Purity/Quality:

99% min ^*data from raw suppliers

1-chloroisoquinoline-7-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloroisoquinoline-7-carbaldehyde

There total 3 articles about 1-Chloroisoquinoline-7-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Methyl formate (107-31-3) + 7-bromo-1-chloroisoquinoline (215453-51-3) → 1-chloroisoquinoline-7-carbaldehyde (223671-53-2)

Guidance literature:

7-bromo-1-chloroisoquinoline; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

Methyl formate; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 2h;

DOI:10.1021/acs.joc.5b02371

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 7-bromo-1-chloroisoquinoline (215453-51-3) → 1-chloroisoquinoline-7-carbaldehyde (223671-53-2)

Guidance literature:

7-bromo-1-chloroisoquinoline; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.bmcl.2004.03.094

Reference yield:

7-bromo-1-chloroisoquinoline (215453-51-3) → 1-chloroisoquinoline-7-carbaldehyde (223671-53-2)

Guidance literature:

upstream raw materials:

N,N-dimethyl-formamide

7-bromo-1-chloroisoquinoline

Methyl formate

Downstream raw materials:

1-Chloro-7-hydroxymethylisoquinoline

Refernces

• 1、 Lafaye, Kevin,Nicolas, Lionel,Gurinot, Amandine,Reymond, Sbastien,Cossy, Janine. "Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis". supporting information. p. 4972 - 4975. Retrieved 2015/01/08.
• 2、 -. "Isoquinolines as urokinase inhibitors". . . Retrieved 2008/06/13.