(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Base Information Edit

Chemical Name:(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
CAS No.:1394346-24-7
Molecular Formula:C₁₃H₈BrCl₂FN₂O₃
Molecular Weight:410.027
Hs Code.:
Mol file:1394346-24-7.mol

Synonyms:(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine Edit

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Technology Process of (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

There total 2 articles about (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 877397-65-4
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

: 691872-15-8
5-bromo-3-hydroxy-2-nitropyridine

: 1394346-24-7
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1394346-24-7
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 20 h / Cooling with ice

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; sulfuric acid; nitric acid; triphenylphosphine; In tetrahydrofuran;

Reference yield: 98.4%

: 1029439-02-8
3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol

: 1394346-24-7
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

: (R)-4-(5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-6-nitropyridin-3-yl)-3-fluorophenol

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In methanol; 1,2-dimethoxyethane; water; Reflux;