4-Isopropyl Phenoxy Acetyl Chloride

Base Information

• Chemical Name: 4-Isopropyl Phenoxy Acetyl Chloride
• CAS No.: 223128-33-4
• Molecular Formula: C11H13 Cl O2
• Molecular Weight: 212.676
• Hs Code.: 2918990090
• Mol file: 223128-33-4.mol

Synonyms:Acetylchloride, [4-(1-methylethyl)phenoxy]- (9CI); 4-Isopropylphenoxyacetyl chloride

Chemical Property of 4-Isopropyl Phenoxy Acetyl Chloride

Chemical Property:

• Vapor Pressure: 0.00469mmHg at 25°C
• Refractive Index: 1.512
• Boiling Point: 276.8°Cat760mmHg
• Flash Point: 103.2°C
• PSA: 26.30000
• Density: 1.128g/cm³
• LogP: 2.95420
• Sensitive.: Moisture Sensitive
• Water Solubility.: Reacts with water.

Purity/Quality:

99% ^*data from raw suppliers

(4-Isopropylphenoxy)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as a primary and secondary intermediate for pharmaceutical.

Technology Process of 4-Isopropyl Phenoxy Acetyl Chloride

There total 6 articles about 4-Isopropyl Phenoxy Acetyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-isopropylphenoxy)acetic acid (1643-16-9) → 2-(4-isopropylphenoxy)acetyl chloride (223128-33-4)

Guidance literature:

With thionyl chloride; for 1h; Reflux;

DOI:10.3390/antibiotics10040438

Reference yield: 94.0%

→ 2-(4-isopropylphenoxy)acetyl chloride (223128-33-4)

Guidance literature:

Reference yield:

oxalyl dichloride (79-37-8) + 2-(4-isopropylphenoxy)acetic acid (1643-16-9) + (S)-4-Benzyl-2-oxazolidinone (90719-32-7) → (S)-4-benzyl-3-[(4-isopropylphenoxy)acetyl]oxazolidine-2-one (223127-28-4) + 2-(4-isopropylphenoxy)acetyl chloride (223128-33-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(4-isopropylphenoxy)acetic acid

oxalyl dichloride

(S)-4-Benzyl-2-oxazolidinone

4-Isopropylphenol

Downstream raw materials:

N-isopropyl-2-(4-isopropylphenoxy)-N-((3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide

Refernces

• 1、 Noncovich, Alain,Priest, Chad,Ung, Jane,Patron, Andrew P.,Servant, Guy,Brust, Paul,Servant, Nicole,Faber, Nathan,Liu, Hanghui,Gonsalves, Nicole S.,Ditschun, Tanya L.. "Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents". . p. 3931 - 3938. Retrieved 2017/07/27.
• 2、 Ozcan, Sevil,Kazi, Aslamuzzaman,Marsilio, Frank,Fang, Bin,Guida, Wayne C.,Koomen, John,Lawrence, Harshani R.,Sebti, Sa?d M.. "Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors". supporting information. p. 3783 - 3805. Retrieved 2013/06/27.