Corynecin IV

Base Information

• Chemical Name: Corynecin IV
• CAS No.: 40958-11-0
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• Mol file: 40958-11-0.mol

Synonyms:Acetamide,N-[1-[(acetyloxy)methyl]-2-hydroxy-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-;Corynecin IV

Chemical Property of Corynecin IV

Chemical Property:

• Melting Point: 134-135 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 548.8±50.0 °C(Predicted)
• PKA: 12.60±0.20(Predicted)
• PSA: 121.45000
• Density: 1.318±0.06 g/cm3(Predicted)
• LogP: 1.61010

Purity/Quality:

98% ^*data from raw suppliers

CorynecinIV ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Corynecin IV is a member of a naturally-occurring complex of chloramphenicol-like acyl nitrophenylpropylamines isolated from Corynebacterium hydrocarboclastus in 1972. Corynecin IV is active against Gram positive and Gram negative bacteria. Although less potent than chloramphenicol, corynecin IV shows a similar species selectivity. Corynecin IV is a chloramphenicol-like acyl nitrophenylpropylamine..

Technology Process of Corynecin IV

There total 11 articles about Corynecin IV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1RS:2RS)-2-acetylamino-3-acetoxy-1-phenyl-propanol-(1) → (1RS,2RS)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-ol (40958-11-0,66569-87-7,109162-22-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; SOCl₂

2: NH₂SO₃H; HNO₃ / anschliessend mit wss. Na₂CO₃

With thionyl chloride; aminosulfonic acid; nitric acid; benzene;

Reference yield:

(1RS,2SR)-1,3-diacetoxy-2-amino-1-(4-nitro-phenyl)-propane; hydrochloride (109162-23-4) → (1RS,2SR)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-ol (40958-11-0,66569-87-7,109162-22-3)

Guidance literature:

With sodium hydrogencarbonate;

Reference yield:

(+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol (119-62-0,716-61-0,2792-51-0,2792-52-1,2964-48-9,3689-55-2,63526-31-8,71115-69-0,140694-64-0) → (1RS,2RS)-3-acetoxy-2-acetylamino-1-(4-nitro-phenyl)-propan-1-ol (40958-11-0,66569-87-7,109162-22-3)

Guidance literature:

With acetic acid;

upstream raw materials:

(1RS,2SR)-1,3-diacetoxy-2-amino-1-(4-nitro-phenyl)-propane; hydrochloride

(1RS,2SR)-2-amino-1-(4-nitro-phenyl)-propane-1,3-diol; hydrochloride

(+/-)-threo-1-(4-nitro-phenyl)-2-amino-1,3-propanediol

acetic anhydride

Downstream raw materials:

(1RS,2RS)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol

(1RS,2RS)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol

N-[1-(4-nitro-benzoyl)-vinyl]-acetamide

N-[1-hydroxymethyl-2-(4-nitro-phenyl)-2-oxo-ethyl]-acetamide