2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide

Base Information

• Chemical Name: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide
• CAS No.: 79499-60-8
• Molecular Formula: BrH*C₁₂H₁₃BrClNO
• Molecular Weight: 383.51
• Mol file: 79499-60-8.mol

Synonyms:2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide

Chemical Property of 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-bromo-2-(2-chlorophenyl)cyclohexanone-d4Hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Amino-6-bromo-2-(2-chlorophenyl)cyclohexanone-d4 Hydrobromide is an isotope labelled intermediate in the synthesis of Ketamine (K165300) metabolites.

Technology Process of 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide

There total 4 articles about 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

norketamine (35211-10-0,83777-65-5) → 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide (79499-60-8)

Guidance literature:

With hydrogen bromide; bromine; at 70 ℃; for 0.166667h;

DOI:10.1021/jo00338a001

Reference yield:

(1-Bromocyclopentyl)(2-chlorophenyl)methanone (6740-86-9) → 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide (79499-60-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) liq. NH₃, 2) HCl / 1) 4 h, 2) i-PrOH

2: 88 percent / various solvent(s) / 0.12 h / 180 °C

3: 82 percent / 48percent aq. HBr, Br₂ / 0.17 h / 70 °C

With hydrogenchloride; ammonia; hydrogen bromide; bromine; In various solvent(s);

DOI:10.1021/jo00338a001

Reference yield:

1-<(2-Chlorophenyl)iminomethyl>cyclopentanol hydrochloride (79499-58-4) → 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide (79499-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / various solvent(s) / 0.12 h / 180 °C

2: 82 percent / 48percent aq. HBr, Br₂ / 0.17 h / 70 °C

With hydrogen bromide; bromine; In various solvent(s);

DOI:10.1021/jo00338a001

upstream raw materials:

norketamine

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

1-<(2-Chlorophenyl)iminomethyl>cyclopentanol hydrochloride

(±)-1-((2-chlorophenyl)(imino)methyl)cyclopentan-1-ol

Refernces

• 1、 -. "COMPOUNDS FOR THERAPEUTIC USE". Paragraph 0512. . Retrieved 2018/03/25.