Technology Process of 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione
There total 7 articles about 2-{2-[4-(3-{(R)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-ethyl}-isoindole-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrahydrofuran; diethyl ether / 2.16 h / -78 - 20 °C
2.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C
2.2: 2 h / -78 - 20 °C
3.1: carbon dioxide / ethanol / Resolution of racemate
4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran / 24 h / 80 °C
5.1: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C
6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 - 50 °C
6.2: 24 h / Reflux
6.3: 2 h / 20 - 90 °C
7.1: caesium carbonate / N,N-dimethyl-formamide
With
tetrakis(triphenylphosphine) palladium(0); carbon dioxide; boron trifluoride diethyl etherate; water; hydroxylamine; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: carbon dioxide / ethanol / Resolution of racemate
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran / 24 h / 80 °C
3.1: water; potassium hydroxide; hydroxylamine / 48 h / 85 °C
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 - 50 °C
4.2: 24 h / Reflux
4.3: 2 h / 20 - 90 °C
5.1: caesium carbonate / N,N-dimethyl-formamide
With
tetrakis(triphenylphosphine) palladium(0); carbon dioxide; water; hydroxylamine; sodium carbonate; caesium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
