(E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE

Base Information

• Chemical Name: (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE
• CAS No.: 17196-75-7
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.203
• Mol file: 17196-75-7.mol

Synonyms:(E)-3-amino-3-(p-tolyl)acrylonitrile

Chemical Property of (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE

Chemical Property:

Purity/Quality:

(E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE

There total 3 articles about (E)-3-AMINO-3-(4-METHYLPHENYL)-2-PROPENENITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

para-methylbenzonitrile (104-85-8) + acetonitrile (75-05-8,26809-02-9) → (E)-3-amino-3-(p-tolyl)acrylonitrile (17196-75-7)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃; for 3h; sonication;

DOI:10.1080/00397910701397144

Reference yield: 50.0%

para-methylbenzonitrile (104-85-8) + acetonitrile (75-05-8,26809-02-9) → 3-amino-3-p-tolylacrylonitrile (17196-75-7,60375-52-2,25354-55-6)

Guidance literature:

para-methylbenzonitrile; acetonitrile; With potassium tert-butylate; In to\\; at 20 ℃;

With water; In diethyl ether; toluene;

DOI:10.1016/j.molcatb.2011.12.005

Reference yield:

→ 3-amino-3-p-tolylacrylonitrile (17196-75-7,60375-52-2,25354-55-6)

Guidance literature:

p-Tolunitril, CH3CN;

DOI:10.1021/ja01047a023

upstream raw materials:

para-methylbenzonitrile

acetonitrile

Downstream raw materials:

2-hydroxyimino-3-oxo-3-p-tolyl-propionitrile

Refernces

• 1、 Ma, Miaofeng,Hou, Guohua,Wang, Junru,Zhang, Xumu. "Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylonitriles". experimental part. p. 506 - 511. Retrieved 2011/06/17.
• 2、 Jagtap, Sachin R.,Bhanushali, Mayur J.,Nandurkar, Nitin S.,Bhanage, Bhalchandra M.. "Ultrasound-assisted synthesis of β-enaminonitriles in the presence of base". . p. 2253 - 2258. Retrieved 2008/02/07.