4,4,4-trichloro-3-hydroxybutanoic acid

Base Information

• Chemical Name: 4,4,4-trichloro-3-hydroxybutanoic acid
• CAS No.: 13159-46-1
• Molecular Formula: C4H5Cl3O3
• Molecular Weight: 207.441
• Mol file: 13159-46-1.mol

Synonyms:4,4,4-Trichloro-3-hydroxy-butyric acid;4,4,4-Trichloro-3-hydroxybutanoic acid;

Chemical Property of 4,4,4-trichloro-3-hydroxybutanoic acid

Chemical Property:

• Vapor Pressure: 5.38E-05mmHg at 25°C
• Refractive Index: 1.541
• Boiling Point: 310.4 °C at 760 mmHg
• Flash Point: 141.5 °C
• Density: 1.71 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-trichloro-3-hydroxybutanoic acid

There total 13 articles about 4,4,4-trichloro-3-hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-trimethylsilyl-4-trichloromethyl-2-oxetanone (344409-08-1) → 4,4,4-trichloro-3-hydroxybutyric acid (13159-46-1)

Guidance literature:

With formic acid; at 90 ℃; for 2h;

Reference yield:

chloral hydrate (302-17-0) + malonic acid (141-82-2) → 4,4,4-trichloro-3-hydroxybutyric acid (13159-46-1)

Guidance literature:

With pyridine; inactive γ.γ.γ-trichloro-β-oxy-butyric acid;

Reference yield:

malonic acid (141-82-2) + chloral (75-87-6) → 4,4,4-trichloro-3-hydroxybutyric acid (13159-46-1)

Guidance literature:

With acetic acid; at 100 ℃; man destilliert den Eisessig und unangegriffenes Chloral ab, bei 124grad die Destillation unterbrechend;

DOI:10.1177/000992280104000707

upstream raw materials:

pyridine

malonic acid

chloral

chloral hydrate

Downstream raw materials:

3-acetoxy-4,4,4-trichloro-butyric acid

malic acid

methyl 4,4,4-trichloro-3-hydroxybutanoate

Refernces

• 1、 Zaitseva, G. S.,Livantsova, L. I.,Bekker, R. A.,Baukov, Yu. I.,Lutsenko, I. F.. "HETEROSUBSTITUTED (Si, Ge) 2-OXETANONES. REACTION OF SILYL- AND GERMYLKETENES WITH POLYFLUORINATED KETONES AND THE CHARACTERISTICS OF 3-SILYL- AND 3-GERMYL-2-OXETANONES". . p. 1867 - 1874. Retrieved 2007/10/02.