(R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether

Base Information

• Chemical Name: (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether
• CAS No.: 136683-78-8
• Molecular Formula: C₁₆H₂₄O₅
• Molecular Weight: 296.364
• Mol file: 136683-78-8.mol

Synonyms:(R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether

Chemical Property of (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether

There total 1 articles about (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Isobutyl (R)-lactate (61597-96-4,73523-02-1) + para-methoxybenzyl chloride (88023-78-3) → (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether (136683-78-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/0040-4039(91)80599-2

Reference yield: 52.0%

isopropenylmagnesium bromide (13291-18-4) + (R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether (136683-78-8) → (3S,4R)-4-(4-Methoxy-benzyloxymethoxy)-2-methyl-pent-1-en-3-ol (136683-79-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at -10 ℃;

DOI:10.1016/0040-4039(91)80599-2

Reference yield:

(R)-i-butyl lactate (p-methoxyphenyl)methoxymethyl ether (136683-78-8) → {(S)-1-[(R)-1-(4-Methoxy-benzyloxymethoxy)-ethyl]-2-methyl-allyloxy}-acetic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / LiBH₄ / tetrahydrofuran / -10 °C

2: 50percent NaOH, n-Bu₄NHSO₄ / benzene / 10 °C

With sodium hydroxide; lithium borohydride; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; benzene;

DOI:10.1016/0040-4039(91)80599-2

upstream raw materials:

Isobutyl (R)-lactate

para-methoxybenzyl chloride

Downstream raw materials:

(3S,4R)-4-(4-Methoxy-benzyloxymethoxy)-2-methyl-pent-1-en-3-ol

[(1R,2R)-1-Acetyl-2-(4-methoxy-benzyloxymethoxy)-propoxy]-acetic acid tert-butyl ester

{(1R,2R)-2-Hydroxy-1-[(R)-1-(4-methoxy-benzyloxymethoxy)-ethyl]-2-methyl-pent-4-ynyloxy}-acetic acid tert-butyl ester

{(E)-(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-5-iodo-1-[(R)-1-(4-methoxy-benzyloxymethoxy)-ethyl]-2-methyl-pent-4-enyloxy}-acetic acid tert-butyl ester

Refernces