Z-GLY-GLY-OSU

Base Information

• Chemical Name: Z-GLY-GLY-OSU
• CAS No.: 32943-08-1
• Molecular Formula: C16H17 N3 O7
• Molecular Weight: 363.327
• Hs Code.: 2925190090
• Mol file: 32943-08-1.mol

Synonyms:2,5-Pyrrolidinedione,1-[[N-[(phenylmethoxy)carbonyl]glycylglycyl]oxy]- (9CI); 2,5-Pyrrolidinedione,1-[[N-[N-[(phenylmethoxy)carbonyl]glycyl]glycyl]oxy]-; Succinimide,N-[[N-(N-carboxyglycyl)glycyl]oxy]-, benzyl ester (8CI); Glycine,N-[N-[(phenylmethoxy)carbonyl]glycyl]-, 2,5-pyrrolidinedione deriv.;N-(Benzyloxycarbonyl)glycylglycine N-hydroxysuccinimide ester

Chemical Property of Z-GLY-GLY-OSU

Chemical Property:

• PKA: 10.97±0.46(Predicted)
• PSA: 131.11000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 0.35590
• Storage Temp.: -15°C
• Solubility.: Acetonitrile (Slightly, Sonicated), DMSO (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

Z-glycyl glycine hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-GLY-GLY-OSU

There total 5 articles about Z-GLY-GLY-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + CbzGlyGly (2566-19-0) → Cbz-Gly-Gly-OSucc (32943-08-1)

Guidance literature:

With benzotriazol-1-ol; In dichloromethane;

DOI:10.1021/jm990226g

Reference yield:

CbzGlyGly (2566-19-0) → Cbz-Gly-Gly-OSucc (32943-08-1)

Guidance literature:

Reference yield:

Cbz-Gly-ONSuc (2899-60-7) → Cbz-Gly-Gly-OSucc (32943-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / Et₃N / tetrahydrofuran; H₂O / 20 °C

2: 100 percent / HOBT / CH₂Cl₂

With benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; water; 1: Condensation / 2: Condensation;

DOI:10.1021/jm990226g

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

CbzGlyGly

Cbz-Gly-ONSuc

Downstream raw materials:

N¹-benzyloxycarbonylglycylglycinamidoethyl-O⁴-benzylhydrogen-L-isoasparagine

N¹-benzyloxycarbonylglycylglycinamidoethyl-N²-tert-butoxycarbonyl-O⁴-benzylhydrogen-L-isoasparagine

(S)-N-{2-[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-ethyl}-3-(2-phosphono-acetylamino)-succinamic acid benzyl ester

N-(N-benzyloxycarbonyldiglycyl)-N-[N-(β-D-galactopyranosyl)carbamoylmethyl]-N-{N,N-bis[N-(β-D-galactopyranosyl)carbamoylmethyl]carbamoylmethyl}amine

Refernces

• 1、 -. "Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof". . . Retrieved 2008/06/13.
• 2、 Gigot,Penninckx. "New compounds: Peptide derivatives of the antitumor agent N-phosphonoacetyl-L-aspartic acid". . p. 275 - 277. Retrieved 2007/10/02.