(2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one

Base Information Edit

Chemical Name:(2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one
CAS No.:220200-88-4
Molecular Formula:C8H10 Cl3 N O2
Molecular Weight:258.532
Hs Code.:
Mol file:220200-88-4.mol

Synonyms:(2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one

Suppliers and Price of (2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one Edit

Chemical Property:

Vapor Pressure:0.000146mmHg at 25°C
Refractive Index:1.564
Boiling Point:332.5°C at 760 mmHg
Flash Point:154.9°C
PSA：29.54000
Density:1.52g/cm³
LogP:2.03190

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one

There total 4 articles about (2R,4R)-4-Methyl-2-trichloro-methyloxazolidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 74-83-9
methyl bromide

: 118916-60-2,97538-67-5
(2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

: 220200-88-4
(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -75 - -65 ℃; for 4h;

Reference yield: 75.0%

: 118916-60-2,97538-67-5
(2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

: 74-88-4
methyl iodide

: 220200-88-4
(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

Guidance literature:: (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 4h;
DOI:10.1002/ejoc.201201472

Reference yield: 63.0%

: 74-88-4
methyl iodide

: 220200-88-4
(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

Guidance literature:: (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 0.833333h;

methyl iodide; In tetrahydrofuran; at -50 - 20 ℃; for 2.08333h;