C₄₅H₆₀N₄O₈

Base Information

• Chemical Name: C₄₅H₆₀N₄O₈
• CAS No.: 1334511-82-8
• Molecular Formula: C₄₅H₆₀N₄O₈
• Molecular Weight: 784.993
• Mol file: 1334511-82-8.mol

Synonyms:C₄₅H₆₀N₄O₈

Chemical Property of C₄₅H₆₀N₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₀N₄O₈

There total 9 articles about C₄₅H₆₀N₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-4'-hydroxybiphenyl (29558-77-8) → C45H60N4O8 (1334511-82-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / butanone / 8 h / Reflux

2.1: n-butyllithium / tert-butyl methyl ether / 2 h / -20 °C / Inert atmosphere

2.2: -60 - 20 °C

2.3: 0.17 h / 20 °C

3.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; toluene / 4 h / Reflux; Inert atmosphere

4.1: cetyltrimethylammonim bromide; potassium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / Reflux

4.2: 0.5 h / pH 1 / Reflux

5.1: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

5.2: 48 h / 20 °C

With dmap; n-butyllithium; cetyltrimethylammonim bromide; palladium diacetate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; potassium hydroxide; In propan-1-ol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; tert-butyl methyl ether; toluene; butanone; 3.1: Suzuki reaction;

DOI:10.1016/j.ejmech.2012.01.054

Reference yield:

C21H38N4O6 + 4′′-(pentyloxy)-1,1′:4′,1′′-terphenyl-4-carboxylic acid (158938-08-0) → C45H60N4O8 (1334511-82-8)

Guidance literature:

4′′-(pentyloxy)-1,1′:4′,1′′-terphenyl-4-carboxylic acid; With dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;

C₂₁H₃₈N₄O₆; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1016/j.ejmech.2012.01.054

Reference yield:

L-proline methyl ester monohydrochloride (2133-40-6) → C45H60N4O8 (1334511-82-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

1.2: 25 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C

4.1: diethylamine / dichloromethane / 2 h / Cooling with ice

5.1: dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 20 °C

5.2: 48 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2012.01.054

upstream raw materials:

4-(4-n-pentyloxyphenyl)phenylboronic acid

Nδ-Boc-Orn(Nα-Fmoc)-Val-Pro-OMe

4′′-(pentyloxy)-1,1′:4′,1′′-terphenyl-4-carboxylic acid

1-Bromopentane

Refernces