4-aminophenethyl benzoate

Base Information

• Chemical Name: 4-aminophenethyl benzoate
• CAS No.: 858855-90-0
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 858855-90-0.mol

Synonyms:4-aminophenethyl benzoate

Chemical Property of 4-aminophenethyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-aminophenethyl benzoate

There total 3 articles about 4-aminophenethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,2,2-trifluoroethyl benzoate (1579-72-2) + 2-(4'-aminophenyl)ethyl alcohol (104-10-9) → 4-aminophenethyl benzoate (858855-90-0)

Guidance literature:

With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)]; In toluene; at 120 ℃; for 2h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201602801

Reference yield:

benzoyl chloride (98-88-4) → 4-aminophenethyl benzoate (858855-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12.33 h / 0 - 20 °C / Inert atmosphere

2: (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] / toluene / 2 h / 120 °C / Inert atmosphere; Schlenk technique

With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)]; triethylamine; In dichloromethane; toluene;

DOI:10.1002/chem.201602801

Reference yield:

benzoic acid-(4-nitro-phenethyl ester) → 4-aminophenethyl benzoate (858855-90-0)

Guidance literature:

With calcium chloride; zinc;

DOI:10.1039/jr9350001819

upstream raw materials:

2,2,2-trifluoroethyl benzoate

2-(4'-aminophenyl)ethyl alcohol

benzoyl chloride

Downstream raw materials:

2-(4-Fluorophenyl)ethanol

1-(2-chloroethyl)-4-fluorobenzene

2-(4-fluorophenyl)ethyl benzoate

Refernces

• 1、 Samanta, Ramesh C.,De Sarkar, Suman,Froehlich, Roland,Grimme, Stefan,Studer, Armido. "N-Heterocyclic carbene (NHC) catalyzed chemoselective acylation of alcohols in the presence of amines with various acylating reagents". . p. 2177 - 2184. Retrieved 2013/05/21.