Methyl 3-butynoate

Base Information

• Chemical Name: Methyl 3-butynoate
• CAS No.: 32804-66-3
• Molecular Formula: C5H6 O2
• Molecular Weight: 98.1014
• Hs Code.: 2916190090
• Mol file: 32804-66-3.mol

Synonyms:Methyl3-butynoate

Chemical Property of Methyl 3-butynoate

Chemical Property:

• Boiling Point: 59-61 °C(Press: 50 Torr)
• PSA: 26.30000
• Density: 0.997±0.06 g/cm3(Predicted)
• LogP: 0.18270
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

MethylBut-3-ynoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl But-3-ynoate is used in preparation of phenylalanine derivatives as non-peptide GLP-1 receptor agonists and sensitizers.

Technology Process of Methyl 3-butynoate

There total 7 articles about Methyl 3-butynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methanol (67-56-1) + 3-butynoic acid (2345-51-9) → methyl 3-butynoate (32804-66-3)

Guidance literature:

With sulfuric acid; at 25 ℃; for 120h;

DOI:10.1021/jo01313a002

Reference yield: 40.0%

methanol (67-56-1) + trans-2,3-dibromo-1,4-dichloro-2-butene (85415-22-1) → methyl 3-butynoate (32804-66-3) + (Z)-1-methoxybut-1-en-3-yne (2798-73-4,3685-19-6,3685-20-9) + methyl buta-2,3-dienoate (18913-35-4) + 1,1,1-trimethoxy-3-butyne (86884-04-0) + 1,1,1-trimethoxy-2-butyne (86884-05-1) + 1,1,1-trimethoxy-2,3-butadiene (85415-23-2)

Guidance literature:

With sodium methylate; for 1h; Product distribution; Mechanism; Heating; other reagent: KOH;

Reference yield: 36.0%

methyl diazoacetate (6832-16-2) + acetylene (74-86-2,25067-58-7) → methyl 3-butynoate (32804-66-3)

Guidance literature:

With copper(II) oxide; at 170 ℃;

DOI:10.1007/BF01168281

upstream raw materials:

diazomethane

3-butynoic acid

methyl diazoacetate

acetylene

Downstream raw materials:

methyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl) acetate

methyl [2-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

methyl [2-(4-chlorophenyl)imidazo[2,1-b][1,3]benzothiazol-3-yl]acetate

C₁₂H₁₂N₄O₄

Refernces

• 1、 Wakabayashi,Saito,Sugihara,Sugimura,Murata. "Some preparation methods of a tricyclo[4.1.0.02,7]hept-4-en-3-one skeleton". . p. 2019 - 2027. Retrieved 2007/10/02.
• 2、 Trieu, Nguyen D.,Elsevier, Cornelis J.,Vrieze, Kees. "CONVENIENT SYNTHESIS OF ALLENYL ESTERS AND AMIDES BY PALLADIUM CATALYZED ALKOXY- AND AMIDO-CARBONYLATION OF ALLENYL AND PROPYNYL HALIDES". . p. C23 - C26. Retrieved 2007/10/02.