QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE

Base Information

• Chemical Name: QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE
• CAS No.: 32743-31-0
• Molecular Formula: C₁₁H₉N₃O₂
• Molecular Weight: 215.211
• Hs Code.: 2933 49 10
• Mol file: 32743-31-0.mol

Synonyms:QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE

Chemical Property of QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE

Chemical Property:

• Vapor Pressure: 5.92E-12mmHg at 25°C
• Melting Point: >250°C
• Refractive Index: 1.706
• Boiling Point: 545.4°C at 760 mmHg
• PKA: 14.49±0.30(Predicted)
• Flash Point: 283.7°C
• PSA: 100.06000
• Density: 1.395g/cm³
• LogP: 2.01710
• Storage Temp.: Store below +30°C.

Purity/Quality:

98%Min ^*data from raw suppliers

Quinoline-2,4-dicarboxylic acid amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE

There total 4 articles about QUINOLINE-2,4-DICARBOXYLIC ACID AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethyl quinoline-2,4-dicarboxylate (7170-24-3) → quinoline-2,4-dicarboxylic acid diamide (32743-31-0)

Guidance literature:

With ammonia; at 85 ℃;

DOI:10.1021/ja01267a025

Reference yield:

quinoline (91-22-5) + formamide (77287-34-4,77287-35-5,60100-09-6) → quinoline-2,4-dicarboxylic acid diamide (32743-31-0)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; at 60 ℃; for 4h;

DOI:10.1016/S0040-4020(01)97191-1

Reference yield:

quinoline-2,4-dicarboxylic acid (5323-57-9) → quinoline-2,4-dicarboxylic acid diamide (32743-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / Erwaermen des erhaltenen Saeurechlorids mit Methanol

2: methanol. NH₃ / 85 °C

With thionyl chloride; ammonia;

DOI:10.1021/ja01267a025

upstream raw materials:

2,4-dimethyl quinoline-2,4-dicarboxylate

quinoline

formamide

quinoline-2,4-dicarboxylic acid

Downstream raw materials:

2,4-diamino-quinoline

Refernces