5-Chloro-2,4-difluoroaniline

Base Information

• Chemical Name: 5-Chloro-2,4-difluoroaniline
• CAS No.: 348-65-2
• Molecular Formula: C6H4ClF2N
• Molecular Weight: 163.554
• Hs Code.: 2921420090
• Mol file: 348-65-2.mol

Synonyms:Aniline,5-chloro-2,4-difluoro- (6CI,8CI);5-Chlor-2,4-difluoranilin;Benzenamine, 5-chloro-2,4-difluoro-;TL8002602;5-Chloro-2,4-difluoro-benzenamine;

Chemical Property of 5-Chloro-2,4-difluoroaniline

Chemical Property:

• Vapor Pressure: 0.124mmHg at 25°C
• Melting Point: 50-51 °C(Solv: ligroine (8032-32-4))
• Refractive Index: 1.543
• Boiling Point: 218.7 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 86.1 °C
• PSA: 26.02000
• Density: 1.459 g/cm³
• LogP: 2.78160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloro-2,4-difluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2,4-difluoroaniline can be used as reactant/reagent in preparation of aminoisoxazoline compds. as agonists of α7-nicotinic acetylcholine receptors.

Technology Process of 5-Chloro-2,4-difluoroaniline

There total 4 articles about 5-Chloro-2,4-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2,4-difluoronitrobenzene (1481-68-1) → 5-chloro-2,4-difluoroaniline (348-65-2)

Guidance literature:

With iron;

DOI:10.1021/ja01510a021 DOI:10.1021/ja01592a073

Reference yield:

1-chloro-2,4-difluorobenzene (1435-44-5) → 5-chloro-2,4-difluoroaniline (348-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 50 °C

2: iron

With sulfuric acid; nitric acid; iron;

DOI:10.1021/ja01592a073

Reference yield:

2,4-Difluor-benzoldiazonium-chlorid (90802-25-8) → 5-chloro-2,4-difluoroaniline (348-65-2)

Guidance literature:

Multi-step reaction with 3 steps

1: water; copper (I)-chloride; concentrated aqueous hydrochloric acid / 0 °C

2: sulfuric acid; nitric acid / 50 °C

3: iron

With hydrogenchloride; sulfuric acid; water; nitric acid; iron; copper(l) chloride;

DOI:10.1021/ja01592a073

upstream raw materials:

5-chloro-2,4-difluoronitrobenzene

1-chloro-2,4-difluorobenzene

2,4-Difluor-benzoldiazonium-chlorid

Downstream raw materials:

(5-chloro-2,4-difluoro-phenoxy)-acetic acid

5-chloro-2,4-difluoro-phenol