N-(2-fluoro-4-nitrophenyl)acetamide

Base Information

• Chemical Name: N-(2-fluoro-4-nitrophenyl)acetamide
• CAS No.: 348-19-6
• Molecular Formula: C8H7 F N2 O3
• Molecular Weight: 198.154
• Hs Code.: 2924299090
• European Community (EC) Number: 669-099-1
• DSSTox Substance ID: DTXSID00392235
• Nikkaji Number: J1.298.325E
• Wikidata: Q82190286
• Mol file: 348-19-6.mol

Synonyms:N-(2-fluoro-4-nitrophenyl)acetamide;348-19-6;2-Fluoro-4-nitroacetanilide;2-Fluoro-4-nitro-acetanilide;2'-FLUORO-4'-NITROACETANILID;MFCD00033912;2-Fluoro-4-niroacetanilide;SCHEMBL8462703;DTXSID00392235;KFSFGCHQQCRZBB-UHFFFAOYSA-N;2-FLUORO-4-NITROACETANILID;VT1112;1-acetylamino-2-fluoro-4-nitrobenzene;AKOS011324062;AS-8394;CS-0206188;FT-0695537

Chemical Property of N-(2-fluoro-4-nitrophenyl)acetamide

Chemical Property:

• Melting Point: 200-201 °C(Solv: ethanol (64-17-5))
• Boiling Point: 391.0±32.0 °C(Predicted)
• PKA: 12.83±0.70(Predicted)
• PSA: 74.92000
• Density: 1.429±0.06 g/cm3(Predicted)
• LogP: 2.28850
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 198.04407025
• Heavy Atom Count: 14
• Complexity: 241

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Fluoro-4-nitrophenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])F

Technology Process of N-(2-fluoro-4-nitrophenyl)acetamide

There total 9 articles about N-(2-fluoro-4-nitrophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-4-nitroaniline (369-35-7) + acetic anhydride (108-24-7) → 2'-fluoro-4'-nitroacetanilide (348-19-6)

Guidance literature:

With sodium acetate; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201500795

Reference yield: 60.0%

N-(4-Nitrophenyl)acetamide (104-04-1) → 2'-fluoro-4'-nitroacetanilide (348-19-6) + N-(2,6-difluoro-4-nitro-phenyl)-acetamide

Guidance literature:

With formic acid; fluorine; at 10 ℃; for 1.75h;

DOI:10.1016/S0022-1139(99)00238-9

Reference yield: 54.0%

N-(2-fluorophenyl)acetamide (399-31-5) → 2'-fluoro-4'-nitroacetanilide (348-19-6)

Guidance literature:

With nitric acid; at 0 - 3 ℃; for 1.08333h;

DOI:10.1002/jhet.5570310639

upstream raw materials:

N-(2-fluorophenyl)acetamide

acetic anhydride

N-(4-Nitrophenyl)acetamide

2-Fluoroaniline

Downstream raw materials:

2-fluoro-4-nitroaniline

4-amino-2-fluoroacetanilide

N-(2-fluoro-4-nitrophenyl)-1-cyclohexene-1,2-dicarboximide

N-(4-amino-2-fluorophenyl)-1-cyclohexene-1,2-dicarboximide

Refernces

• 1、 Schmidt, Bernd,Elizarov, Nelli,Riemer, Nastja,H?lter, Frank. "Acetamidoarenediazonium Salts: Opportunities for Multiple Arene Functionalization". . p. 5826 - 5841. Retrieved 2015/09/15.
• 2、 Chambers, Richard D.,Hutchinson, John,Sparrowhawk, Matthew E.,Sandford, Graham,Moilliet, John S.,Thomson, Julie. "Elemental fluorine Part 12. Fluorination of 1,4-disubstituted aromatic compounds". . p. 169 - 173. Retrieved 2007/10/03.