N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE

Base Information

• Chemical Name: N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE
• CAS No.: 342-52-9
• Molecular Formula: C8H7 F N2 O3
• Molecular Weight: 198.154
• Hs Code.: 2924299090
• Mol file: 342-52-9.mol

Synonyms:Acetanilide,2'-fluoro-6'-nitro- (8CI)

Chemical Property of N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE

Chemical Property:

• Vapor Pressure: 1.05E-05mmHg at 25°C
• Refractive Index: 1.594
• Boiling Point: 371.2°C at 760 mmHg
• PKA: 12.75±0.70(Predicted)
• Flash Point: 178.3°C
• PSA: 74.92000
• Density: 1.429g/cm³
• LogP: 2.28850

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Fluoro-6-nitrophenyl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE

There total 6 articles about N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-fluoro-6-nitroaniline (17809-36-8) + acetyl chloride (75-36-5) → N-(2-fluoro-6-nitrophenyl)acetamide (342-52-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24.25h;

Reference yield: 80.0%

N-(2-fluorophenyl)acetamide (399-31-5) → N-(2-fluoro-6-nitrophenyl)acetamide (342-52-9)

Guidance literature:

With Iron(III) nitrate nonahydrate; N-hydroxyphthalimide; In 1,2-dichloro-ethane; at 50 ℃; for 10h; regioselective reaction;

DOI:10.1039/c8ob00841h

Reference yield:

2-Fluoroaniline (348-54-9) → N-(2-fluoro-6-nitrophenyl)acetamide (342-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C / Inert atmosphere

2: Iron(III) nitrate nonahydrate; N-hydroxyphthalimide / 1,2-dichloro-ethane / 10 h / 50 °C

With Iron(III) nitrate nonahydrate; N-hydroxyphthalimide; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1039/c8ob00841h

upstream raw materials:

N-(2-fluorophenyl)acetamide

acetic anhydride

2-fluoro-6-nitroaniline

acetyl chloride

Downstream raw materials:

N-(2-amino-6-fluorophenyl)acetamide

3-fluorobenzene-1,2-diamine

2-fluoro-6-nitroaniline

2-bromo-3-fluoronitrobenzene

Refernces

• 1、 Carta, Antonio,Bua, Alessandra,Corona, Paola,Piras, Sandra,Briguglio, Irene,Molicotti, Paola,Zanetti, Stefania,Laurini, Erik,Aulic, Suzana,Fermeglia, Maurizio,Pricl, Sabrina. "Design, synthesis and antitubercular activity of 4-alkoxy-triazoloquinolones able to inhibit the M. tuberculosis DNA gyrase". . p. 399 - 415. Retrieved 2018/10/31.
• 2、 -. "FLUORO SUBSTITUTED PYRIMIDINE COMPOUNDS AS JAK3 INHIBITORS". Page/Page column 17. . Retrieved 2012/03/08.