Technology Process of trans-[4-(4-aminophenyl)cyclohexyl]acetic acid methyl ester
There total 4 articles about trans-[4-(4-aminophenyl)cyclohexyl]acetic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
1.2: 5 h / 25 °C
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 25 °C
3.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
4.1: caesium carbonate; palladium diacetate; XPhos / toluene / 10 h / 180 °C / Sealed tube; Inert atmosphere
5.1: water; hydrogenchloride / methanol / 4 - 7 °C
With
hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; sodium hydride; caesium carbonate; triethylamine; XPhos;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 25 °C
2: triethylamine / dichloromethane / 5 h / 0 - 20 °C
3: caesium carbonate; palladium diacetate; XPhos / toluene / 10 h / 180 °C / Sealed tube; Inert atmosphere
4: water; hydrogenchloride / methanol / 4 - 7 °C
With
hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; palladium diacetate; caesium carbonate; triethylamine; XPhos;
In
methanol; dichloromethane; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
2: caesium carbonate; palladium diacetate; XPhos / toluene / 10 h / 180 °C / Sealed tube; Inert atmosphere
3: water; hydrogenchloride / methanol / 4 - 7 °C
With
hydrogenchloride; water; palladium diacetate; caesium carbonate; triethylamine; XPhos;
In
methanol; dichloromethane; toluene;