2-[(4-Chlorophenyl)amino]acetohydrazide

Base Information

• Chemical Name: 2-[(4-Chlorophenyl)amino]acetohydrazide
• CAS No.: 2371-31-5
• Molecular Formula: C8H10ClN3O
• Molecular Weight: 199.64
• Hs Code.: 2928000090
• NSC Number: 190329
• DSSTox Substance ID: DTXSID10307178
• Wikidata: Q82054536
• Mol file: 2371-31-5.mol

Synonyms:2-[(4-chlorophenyl)amino]acetohydrazide;2371-31-5;2-(4-chloroanilino)acetohydrazide;2-((4-Chlorophenyl)amino)acetohydrazide;2-(4-Chlorophenylamino)acetohydrazide;NSC 190329;2-[(4-chlorophenyl)amino]acetohydrazide (non-preferred name);NSC190329;Cambridge id 5353323;Oprea1_017087;Oprea1_193396;SCHEMBL2319538;DTXSID10307178;BBL013454;MFCD00463072;STK279211;AKOS000295994;NSC-190329;SB86273;4-chlorophenylaminoacetic acid hydrazide;VS-03845;BB 0221460;CS-0318272;FT-0678937;(4-Chloro-phenylamino)-acetic acid hydrazide

Chemical Property of 2-[(4-Chlorophenyl)amino]acetohydrazide

Chemical Property:

• Vapor Pressure: 1.26E-09mmHg at 25°C
• Refractive Index: 1.633
• Boiling Point: 486.7 °C at 760 mmHg
• Flash Point: 248.1 °C
• PSA: 67.15000
• Density: 1.358 g/cm³
• LogP: 1.90600
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.0512396
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

98%min ^*data from raw suppliers

2-[(4-Chlorophenyl)amino]acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NCC(=O)NN)Cl
• Uses: 2-[(4-chlorophenyl)amino]acetohydrazide is a useful reactant and reagent in the synthesis of various organic compounds.

Technology Process of 2-[(4-Chlorophenyl)amino]acetohydrazide

There total 8 articles about 2-[(4-Chlorophenyl)amino]acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-((4-chlorophenyl)amino)acetate (2521-89-3) → 2-((4-chlorophenyl)amino)acetohydrazide (2371-31-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.08.027

Reference yield:

ethyl N-(4-chlorophenyl)-N-(trifluoroacetyl)glycinate → 2-((4-chlorophenyl)amino)acetohydrazide (2371-31-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield:

4-chloro-aniline (106-47-8) → 2-((4-chlorophenyl)amino)acetohydrazide (2371-31-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / water / 3 h / 90 °C

2: hydrazine hydrate / 0.01 h / Microwave irradiation

With hydrazine hydrate; sodium acetate; In water;

DOI:10.1111/cbdd.12118

upstream raw materials:

ethyl 2-((4-chlorophenyl)amino)acetate

N-(4-chlorophenyl)glycine

4-chloro-aniline

N-(4-chlorophenyl)-2,2,2-trifluoroacetamide

Downstream raw materials:

1-(4-chlorophenylaminoacetyl)-4-(4-phenylbenzyl)-thiosemicarbazide

{2-(4-chlorophenyl)}-2,3,5a,6,11,11a-hexahydro-6,11-[1',2']-benzenobenzo[g]-1H-[1,2,4]triazino[1,2-b]phthalayine-4,5,12-trione

2-[1-oxo-2-[(4-chlorophenyl)amino]-ethyl]-2,3,4a,5,10,10a-hexahydro-5,10-[1',2']-benzenobenzo[g]-phthalazine-1,4-dione

(E)-N'-(3-bromo-4-fluorobenzylidene)-2-(4-chlorophenylamino)acetohydrazide

Refernces

• 1、 Maingot, Lucie,Elbakali, Jamal,Dumont, Julie,Bosc, Damien,Cousaert, Nicolas,Urban, Agathe,Deglane, Gaelle,Villoutreix, Bruno,Nagase, Hideaki,Sperandio, Olivier,Leroux, Florence,Deprez, Benoit,Deprez-Poulain, Rebecca. "Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group". . p. 244 - 261. Retrieved 2013/10/01.
• 2、 -. "CFTR INHIBITOR COMPOUNDS AND USES THEREOF". Page/Page column 143. . Retrieved 2008/12/04.