3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester

Base Information

• Chemical Name: 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester
• CAS No.: 136749-44-5
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• Mol file: 136749-44-5.mol

Synonyms:3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester

Chemical Property of 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester

There total 2 articles about 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride (32404-28-7) → 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester (136749-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / aq. NaNO₂

2: H₂SO₄

With sulfuric acid; sodium nitrite;

DOI:10.1139/v97-612

Reference yield:

ethanol (64-17-5) + (S)-3-(3-ACETYL-4-HYDROXY-PHENYL)-2-HYDROXY-PROPIONIC ACID (136749-43-4) → 3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester (136749-44-5)

Guidance literature:

In chloroform; for 12h; Yield given; Heating; strongly acidic ion exchanger;

Reference yield:

3-(3'-acetyl-4'-hydroxyphenyl)-(S)-lactic acid ethyl ester (136749-44-5) → (2S)-3-(3,4-dihydroxyphenyl)-2-hydroxypropionic acid (42085-50-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; at 40 ℃; for 0.5h;

upstream raw materials:

ethanol

(S)-3-(3-ACETYL-4-HYDROXY-PHENYL)-2-HYDROXY-PROPIONIC ACID

(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride

Downstream raw materials:

(2S)-3-(3,4-dihydroxyphenyl)-2-hydroxypropionic acid

(+)-(S)-methyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate

(S)-3-(3,4-Dihydroxy-phenyl)-2-hydroxy-propionic acid ethyl ester

(S)-(-)-3-(3,4-Dihydroxybenzyl)-8-methyl-1,4-dioxa-8-azaspiro<4,5>decan-2-on

Refernces

• 1、 Wuensch, Bernhard,Zott, Matthias. "Chiral 2-Benzopyran-3-carboxylates by Oxa-Pictet-Spengler Reaction of (S)-3-Phenyllactic Acid Derivatives". . p. 39 - 46. Retrieved 2007/10/02.