2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid

Base Information

• Chemical Name: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid
• CAS No.: 32445-89-9
• Molecular Formula: C11H11 F3 O2
• Molecular Weight: 232.202
• Hs Code.: 2916399090
• Mol file: 32445-89-9.mol

Synonyms:Hydratropicacid, a-methyl-p-(trifluoromethyl)-(8CI)

Chemical Property of 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid

Chemical Property:

• Vapor Pressure: 0.00158mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 282.6°C at 760 mmHg
• Flash Point: 124.7°C
• PSA: 37.30000
• Density: 1.26g/cm³
• LogP: 3.06760
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

α,α-Dimethyl-4-(trifluoromethyl)benzeneaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid can be used for preparation of triazoles and related compounds as 11β-hydroxysteroid dehydrogenase 1 inhibitors. Used for preparation of triazoles and related compounds as 11β-hydroxysteroid dehydrogenase 1 inhibitors.

Technology Process of 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid

There total 4 articles about 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoate (476429-18-2) → 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoic acid (32445-89-9)

Guidance literature:

methyl 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoate; With sodium hydroxide; In methanol; Reflux;

With hydrogenchloride; In methanol; water; at 0 ℃;

DOI:10.1021/ja311259x

Reference yield:

(4-trifluoromethylphenyl)acetic acid ethyl ester (721-63-1) → 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoic acid (32445-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 48.5 h / 0 - 23 °C

2: potassium hydroxide; water / methanol / 18 h / pH 2 / Heating / reflux

With potassium hydroxide; water; sodium hydride; In methanol; N,N-dimethyl-formamide;

Reference yield:

4-Trifluoromethylphenylacetic acid (32857-62-8) → 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoic acid (32445-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 48 h / Heating / reflux

2: sodium hydride / N,N-dimethyl-formamide / 48.5 h / 0 - 23 °C

3: potassium hydroxide; water / methanol / 18 h / pH 2 / Heating / reflux

With potassium hydroxide; sulfuric acid; water; sodium hydride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoate

4-Trifluoromethylphenylacetic acid

(4-trifluoromethylphenyl)acetic acid ethyl ester

4-(Trifluoromethyl)phenylacetonitrile

Downstream raw materials:

2,3-dimethyl-2,3-bis(4-(trifluoromethyl)phenyl)butane

2-methyl-2-(4-(trifluoromethyl)phenyl)propanamide

C₁₁H₁₄F₃N

2-methyl-2-(4-(trifluoromethyl)phenyl)propanal

Refernces

• 1、 -. "ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES". Paragraph 0060; 0062. . Retrieved 2019/06/09.
• 2、 -. "NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF". Page/Page column 69. . Retrieved 2008/12/06.