1,3-propanediol bis-acetylsalicylate

Base Information

• Chemical Name: 1,3-propanediol bis-acetylsalicylate
• CAS No.: 19283-97-7
• Molecular Formula: C₂₁H₂₀O₈
• Molecular Weight: 400.385
• Mol file: 19283-97-7.mol

Synonyms:1,3-propanediol bis-acetylsalicylate

Chemical Property of 1,3-propanediol bis-acetylsalicylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-propanediol bis-acetylsalicylate

There total 3 articles about 1,3-propanediol bis-acetylsalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dibromo-propane (109-64-8) + aspirin (50-78-2,98201-60-6) → 1,3-propanediol bis-acetylsalicylate (19283-97-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 - 100 ℃;

DOI:10.1007/s00044-020-02674-6

Reference yield:

sodium O-acetylsalicylate (493-53-8) + 1,3-dibromo-propane (109-64-8) → 1,3-propanediol bis-acetylsalicylate (19283-97-7)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield:

→ 1,3-propanediol bis-acetylsalicylate (19283-97-7)

Guidance literature:

1,3-Propandioldisalicylat, Ac2O;

upstream raw materials:

sodium O-acetylsalicylate

1,3-dibromo-propane

aspirin

Refernces

• 1、 -. "Process for the preparation of a pharmacologically active chemical combination". Example 19. . Retrieved 2010/01/31.