4-BOC-2-MORPHOLINECARBALDEHYDE

Base Information

• Chemical Name: 4-BOC-2-MORPHOLINECARBALDEHYDE
• CAS No.: 218594-02-6
• Molecular Formula: C10H17 N O4
• Molecular Weight: 215.249
• Hs Code.: 2934999090
• Mol file: 218594-02-6.mol

Synonyms:4-(tert-Butoxycarbonyl)-2-formylmorpholine

Chemical Property of 4-BOC-2-MORPHOLINECARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.516
• Boiling Point: 309.1°Cat760mmHg
• PKA: -2.60±0.40(Predicted)
• Flash Point: 140.7°C
• PSA: 55.84000
• Density: 1.18g/cm³
• LogP: 0.75910
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

N-Boc-2-Morpholinecarbaldehyde 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BOC-2-MORPHOLINECARBALDEHYDE

There total 2 articles about 4-BOC-2-MORPHOLINECARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate (135065-69-9) → 2-formylmorpholine-4-carboxylic acid tert-butyl ester (218594-02-6)

Guidance literature:

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1.16667h;

With triethylamine; In dichloromethane; for 0.5h;

Reference yield:

→ 2-formylmorpholine-4-carboxylic acid tert-butyl ester (218594-02-6)

Guidance literature:

Reference yield:

(1R,2S)-1-amino-2-phenylcyclopropane (95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7) + 2-formylmorpholine-4-carboxylic acid tert-butyl ester (218594-02-6) → C19H28N2O3

Guidance literature:

(1R,2S)-1-amino-2-phenylcyclopropane; 2-formylmorpholine-4-carboxylic acid tert-butyl ester; With acetic acid; In methanol; at 20 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 18h;

upstream raw materials:

tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate

Downstream raw materials:

1,1-dimethylethyl-2-[(4-fluorophenyl)(hydroxy)methyl]-4-morpholinecarboxylate

tert-butyl 2-((4-benzylpiperazin-1-yl)methyl)morpholine-4-carboxylate

Refernces

• 1、 -. "8-Substituted isoquinoline derivative and the use thereof". Page/Page column 145. . Retrieved 2010/11/03.