6-chloro-2-methoxy-3-nitrotoluene

Base Information

• Chemical Name: 6-chloro-2-methoxy-3-nitrotoluene
• CAS No.: 55289-26-4
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.609
• Mol file: 55289-26-4.mol

Synonyms:6-chloro-2-methoxy-3-nitrotoluene

Chemical Property of 6-chloro-2-methoxy-3-nitrotoluene

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

3-Chloro-2-methyl-6-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-methoxy-3-nitrotoluene

There total 5 articles about 6-chloro-2-methoxy-3-nitrotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-chloro-2-methyl-6-nitro-phenol (83577-91-7) + dimethyl sulfate (77-78-1) → 6-chloro-2-methoxy-3-nitrotoluene (55289-26-4)

Guidance literature:

With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane; water;

DOI:10.1039/c39820000741

Reference yield:

2,4-dichloronitrobenzene (611-06-3) → 6-chloro-2-methoxy-3-nitrotoluene (55289-26-4)

Guidance literature:

In methanol; n-heptane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3-chloro-o-cresol (3260-87-5) → 6-chloro-2-methoxy-3-nitrotoluene (55289-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / conc. HNO₃ / propionic acid / -10 °C

2: 93 percent / KOH, nBu₄NBr / CH₂Cl₂; H₂O

With potassium hydroxide; tetrabutylammomium bromide; nitric acid; In dichloromethane; water; propionic acid;

DOI:10.1039/c39820000741

upstream raw materials:

3-chloro-2-methyl-6-nitro-phenol

dimethyl sulfate

methanol

2,6-dichloro-3-nitrotoluene

Downstream raw materials:

4-Chloro-2-methoxy-3-methyl-phenylamine

2-Methoxy-6-chloro-3-nitrobenzyl bromide

8-(2-Methoxy-3-amino-6-chlorobenzyloxy)-2-methylquinoline

8-(2-Methoxy-3-nitro-6-chlorobenzyloxy)-2-methylquinoline

Refernces

• 1、 Heitsch, Holger,Wagner, Adalbert,Schoelkens, Bernward A.,Wirth, Klaus. "Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors". . p. 327 - 332. Retrieved 2007/10/03.