5-ALPHA-DIHYDRO SUBSTANCE 'S'

Base Information

• Chemical Name: 5-ALPHA-DIHYDRO SUBSTANCE 'S'
• CAS No.: 312-99-2
• Molecular Formula: C21H32 O4
• Molecular Weight: 348.483
• Mol file: 312-99-2.mol

Synonyms:3,20-Allopregnanedione,17a,21-dihydroxy- (5CI);17,21-Dihydroxy-5a-pregnane-3,20-dione;17a,21-Dihydroxy-5a-pregnane-3,20-dione; 5a-Pregnane-17a,21-diol-3,20-dione

Chemical Property of 5-ALPHA-DIHYDRO SUBSTANCE 'S'

Chemical Property:

• PSA: 74.60000
• LogP: 2.89070

Purity/Quality:

97% ^*data from raw suppliers

5-ALPHA-PREGNAN-17.21-DIOL-3,20-DIONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ALPHA-DIHYDRO SUBSTANCE 'S'

There total 11 articles about 5-ALPHA-DIHYDRO SUBSTANCE 'S' which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione (1639-45-8) → 17α-21-dihydroxy-5-α-pregnane-3,20-dione (312-99-2)

Guidance literature:

With potassium hydroxide; In methanol; for 1h;

DOI:10.1007/BF00764822

Reference yield: 34.0%

Cortexolone (152-58-9) → 3β,5α-Tetrahydro Reichstein's Substance S (68-60-0,601-01-4,601-03-6,7635-25-8,7694-32-8,97170-01-9,516-47-2) + 17α-21-dihydroxy-5-α-pregnane-3,20-dione (312-99-2)

Guidance literature:

In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;

DOI:10.1016/0039-128X(95)00071-W

Reference yield: 8.0%

cortexolone 21-acetate (640-87-9) → 17α-21-dihydroxy-5-α-pregnane-3,20-dione (312-99-2)

Guidance literature:

In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436, potato dextrose broth;

DOI:10.1016/0039-128X(95)00071-W

upstream raw materials:

Cortexolone

3β,21-Diacetoxy-5α-pregn-17-ene

21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione

cortexolone 21-acetate

Downstream raw materials:

Allo-Tetrahydrodeoxycortisol

allotetrahydro-11-deoxycolesterol 21-glucuronide

cortexolone 21-acetate

11α,17α,21-trihydroxy-5α-pregnane-3,20-dione

Refernces

• 1、 Holland, Herbert L.. "Biotransformation of corticosteroids by Penicillium decumbens ATCC 10436". . p. 646 - 649. Retrieved 2007/10/02.
• 2、 Gerasimova, M. L.,Gusarova, T. I.,Ryzhkova, V. M.,Bykova, T. M.,Alekseeva, L. M.. "SYNTHESIS AND MICROBIOLOGICAL HYDROXYLATION OF 16α,17α-DIHYDROXY-SUBSTITUTED 20-OXO-5α-PREGNANES". . p. 863 - 868. Retrieved 2007/10/02.