6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
• CAS No.: 215798-19-9
• Molecular Formula: C9H10BrN^.HCl
• Molecular Weight: 248.55
• Hs Code.: 2933499090
• Mol file: 215798-19-9.mol

Synonyms:Isoquinoline,6-bromo-1,2,3,4-tetrahydro-, hydrochloride (9CI);

Chemical Property of 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000303mmHg at 25°C
• Melting Point: 131-132 °C(Solv: ethanol (64-17-5))
• Boiling Point: 316.4 °C at 760 mmHg
• Flash Point: 145.1 °C
• PSA: 12.03000
• LogP: 3.22560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

There total 3 articles about 6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-bromo-3,4-dihydroisoquinolin-1(2H)-one (147497-32-3) → 6-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride (215798-19-9)

Guidance literature:

6-bromo-3,4-dihydroisoquinolin-1(2H)-one; With dodecacarbonyl-triangulo-triruthenium; 1,1,3,3-tetramethyldisilazane; In toluene; at 20 - 50 ℃; for 24.17h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; toluene; at 20 ℃; for 0.5h;

DOI:10.1002/adsc.201200835

Reference yield:

6-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline (893566-74-0) → 6-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride (215798-19-9)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃; for 2h;

Reference yield:

6-bromo-2-tert-butyl-1,2,3,4-tetrahydroisoquinoline (1189171-86-5) → 6-bromo-1,2,3,4-tetrahydroisoquinoline hydrochloride (215798-19-9)

Guidance literature:

6-bromo-2-tert-butyl-1,2,3,4-tetrahydroisoquinoline; With carbonochloridic acid 1-chloro-ethyl ester; Reflux;

With methanol; for 4h; Reflux;

DOI:10.1080/00397910902730911

upstream raw materials:

6-bromo-2-tert-butyl-1,2,3,4-tetrahydroisoquinoline

6-bromo-3,4-dihydroisoquinolin-1(2H)-one

6-bromo-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

(R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride

2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Refernces

• 1、 Reeves, Jonathan T.,Tan, Zhulin,Marsini, Maurice A.,Han, Zhengxu S.,Xu, Yibo,Reeves, Diana C.,Lee, Heewon,Lu, Bruce Z.,Senanayake, Chris H.. "A practical procedure for reduction of primary, secondary and tertiary amides to amines". supporting information. p. 47 - 52. Retrieved 2013/03/13.