Technology Process of 7-chloro-3-(2-chlorobenzyl)-5-(4-hydroxyphenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one
There total 6 articles about 7-chloro-3-(2-chlorobenzyl)-5-(4-hydroxyphenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran / 1.58 h / 18 - 28 °C
1.2: 19 h / 42 °C
2.1: acetic acid / 7 h / 130 °C
3.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 16 h / 20 - 90 °C / Inert atmosphere
4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 2 h / 85 °C / Inert atmosphere
5.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
5.2: 1 h / -78 °C / Inert atmosphere
6.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
With
potassium tert-butylate; boron tribromide; sodium hydride; sodium carbonate; acetic acid; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / 7 h / 130 °C
2.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 16 h / 20 - 90 °C / Inert atmosphere
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 2 h / 85 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
With
potassium tert-butylate; boron tribromide; sodium carbonate; acetic acid; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; toluene;