Thieno[3,2-c]pyridin-4-amine

Base Information

• Chemical Name: Thieno[3,2-c]pyridin-4-amine
• CAS No.: 215453-35-3
• Molecular Formula: C7H6N2S
• Molecular Weight: 150.204
• Hs Code.: 2934999090
• European Community (EC) Number: 822-048-9
• DSSTox Substance ID: DTXSID70590867
• Wikidata: Q82484485
• Mol file: 215453-35-3.mol

Synonyms:Thieno[3,2-c]pyridin-4-amine;215453-35-3;Thieno[3,2-c]pyridin-4-amine (9CI);SCHEMBL761059;4-amino-thieno[3,2-c]pyridine;DTXSID70590867;thieno[3,2-c]pyridin-4-ylamine;LIVYKAHFQBZQRL-UHFFFAOYSA-N;MFCD11870051;AKOS009547567;CCG-322924;AS-43585;DB-003457;CS-0081734;EN300-42300;F8880-5812

Chemical Property of Thieno[3,2-c]pyridin-4-amine

Chemical Property:

• Vapor Pressure: 8.74E-05mmHg at 25°C
• Refractive Index: 1.763
• Boiling Point: 340.2 °C at 760 mmHg
• Flash Point: 159.5 °C
• PSA: 67.15000
• Density: 1.383 g/cm³
• LogP: 2.45970
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 150.02516937
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

Thieno[3,2-c]pyridin-4-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C2=C1SC=C2)N

Technology Process of Thieno[3,2-c]pyridin-4-amine

There total 3 articles about Thieno[3,2-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-phenoxythieno[3,2-c]pyridine → thieno[3,2-c]pyridin-4-amine (215453-35-3)

Guidance literature:

With ammonium acetate; at 150 ℃; for 72h; Inert atmosphere;

Reference yield:

4-chlorothieno[3,2-c]pyridine (27685-94-5) → thieno[3,2-c]pyridin-4-amine (215453-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH; PhOH / 2 h / 140 °C

2: NH₄OAc / 72 h / 155 °C

With potassium hydroxide; ammonium acetate; phenol; 1: Substitution / 2: Substitution;

DOI:10.1016/S0960-894X(99)00483-7

Reference yield:

thieno[3,2-c]pyridin-4-ol (27685-92-3) → thieno[3,2-c]pyridin-4-amine (215453-35-3)

Guidance literature:

With ammonium acetate; at 155 ℃; for 72h;

DOI:10.1016/S0960-894X(99)00483-7

upstream raw materials:

thieno[3,2-c]pyridin-4-ol

4-chlorothieno[3,2-c]pyridine

Downstream raw materials:

2-(4-benzoylamino-thieno[3,2-c]pyridin-2-ylmethyl)-2-tert-butoxycarbonylamino-malonic acid diethyl ester

N-(2-hydroxymethyl-thieno[3,2-c]pyridin-4-yl)-benzamide

N-(thieno[3,2-c]pyridin-4-yl)benzamide

Refernces

• 1、 -. "ENZYME INHIBITORS". . . Retrieved 2021/02/26.
• 2、 Rewinkel,Lucas,Smit,Noach,Van Dinther,Rood,Jenneboer,Van Boeckel. "Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors". . p. 2837 - 2842. Retrieved 2007/10/03.