Technology Process of (+)-7α-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
There total 2 articles about (+)-7α-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)styrene;
With
Schwartz's reagent;
In
dichloromethane;
at 20 ℃;
for 0.25h;
Inert atmosphere;
With
C36H30CuNO2P(1+)*CF3O3S(1-);
In
diethyl ether; dichloromethane;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
canrenone;
With
chloro-trimethyl-silane;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 15h;
Inert atmosphere;
DOI:10.1039/c2cc37155c
- Guidance literature:
-
With
C36H30NO2P*Cu(1+)*CF3O3S(1-);
In
diethyl ether; dichloromethane;
for 0.166667h;
Inert atmosphere;
With
chloro-trimethyl-silane;
In
diethyl ether; dichloromethane;
at 20 ℃;
for 15h;
With
water; ammonium chloride;
In
diethyl ether; dichloromethane;
