N,N-DIMETHYL-2(R)-MORPHOLINMETHANAMINE

Base Information

• Chemical Name: N,N-DIMETHYL-2(R)-MORPHOLINMETHANAMINE
• CAS No.: 214273-19-5
• Molecular Formula: C7H16N2O
• Molecular Weight: 144.217
• Hs Code.: 2934999090
• Mol file: 214273-19-5.mol

Synonyms:N,N-Dimethyl-(R)-(morpholin-2-yl)methanamine;

Chemical Property of N,N-DIMETHYL-2(R)-MORPHOLINMETHANAMINE

Chemical Property:

• Vapor Pressure: 0.352mmHg at 25°C
• Refractive Index: 1.443
• Boiling Point: 198.8 °C at 760 mmHg
• PKA: 8.81±0.40(Predicted)
• Flash Point: 74 °C
• PSA: 24.50000
• Density: 0.931 g/cm³
• LogP: -0.13480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-N,N-Dimethyl-1-(morpholin-2-yl)methanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIMETHYL-2(R)-MORPHOLINMETHANAMINE

There total 3 articles about N,N-DIMETHYL-2(R)-MORPHOLINMETHANAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-benzyl-2-(N,N-dimethylaminomethyl)morpholine (122894-38-6) → (R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine (214273-19-5,214273-18-4)

Guidance literature:

With hydrazine hydrate; palladium-carbon; In ethanol;

Reference yield:

(4-benzylmorpholin-2-yl)methanamine (110859-47-7,140646-11-3) → (R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine (214273-19-5,214273-18-4)

Guidance literature:

Multi-step reaction with 2 steps

2: 1.) HCOOH, 2.) NH₂NH₂ / 2.) Pd/C

With formic acid; hydrazine; palladium on activated charcoal;

DOI:10.1016/S0960-894X(98)00390-4

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-(4-benzylmorpholin-2-yl)methanamine (186293-55-0) → (R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine (214273-19-5,214273-18-4)

Guidance literature:

With formic acid; hydrazine; palladium on activated charcoal; Yield given. Multistep reaction;

DOI:10.1016/S0960-894X(98)00390-4

upstream raw materials:

formaldehyd

(S)-(4-benzylmorpholin-2-yl)methanamine

(4-benzylmorpholin-2-yl)methanamine

(S)-4-benzyl-2-(N,N-dimethylaminomethyl)morpholine

Downstream raw materials:

(S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid

Refernces

• 1、 Sakurai, Nobuhiro,Sano, Mitsuharu,Hirayama, Fumihiro,Kuroda, Tsuyoshi,Uemori, Satoru,Moriguchi, Akihiko,Yamamoto, Katsuhiro,Ikeda, Yoshifumi,Kawakita, Takeshi. "Synthesis and structure-activity relationships of 7-(2- aminoalkyl)morpholinoquinolones as anti-helicobacter pylori agents". . p. 2185 - 2190. Retrieved 2007/10/03.