2,2-(Bromoethyl)thiophene

Base Information

• Chemical Name: 2,2-(Bromoethyl)thiophene
• CAS No.: 26478-16-0
• Molecular Formula: C6H7BrS
• Molecular Weight: 191.092
• Hs Code.: 2934999090
• Mol file: 26478-16-0.mol

Synonyms:2-(2-Bromoethyl)thiophene;2-(2-Thienyl)-1-bromoethane;2-(2-Thienyl)ethyl bromide;Bromoethylthiophene;Thiophene, 2-(2-bromoethyl)-;

Chemical Property of 2,2-(Bromoethyl)thiophene

Chemical Property:

• Appearance/Colour: white crystal
• Boiling Point: 205.751 °C at 760 mmHg
• Flash Point: 78.236 °C
• PSA: 28.24000
• Density: 1.53 g/cm³
• LogP: 2.68550
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly), Hexane (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Thienyl)ethylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(2-Thienyl)ethyl Bromide is an halogenated thiophene derivative used in the synthesis of C8813, a potent analgesic.

Technology Process of 2,2-(Bromoethyl)thiophene

There total 4 articles about 2,2-(Bromoethyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-thiophenethanol (5402-55-1) → 2-(2-Bromoethyl)thiophene (26478-16-0)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 0 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9cc10048b

Reference yield:

2-thiophenethanol (5402-55-1) + phosphorus tribromide (7789-60-8) → 2-(2-Bromoethyl)thiophene (26478-16-0) + ethyl 2-oxo-4-(2-thienyl)butyrate (85918-84-9)

Guidance literature:

With pyridine; In benzene;

Reference yield:

2-thiophenethanol (5402-55-1) + phosphorus tribromide (7789-60-8) → 2-(2-Bromoethyl)thiophene (26478-16-0)

Guidance literature:

In tetrachloromethane;

upstream raw materials:

2-thiophenethanol

phosphorus tribromide

Downstream raw materials:

(R)-3-[N-2-(2-thienyl)ethyl]amino-5-phenylchroman hydrochloride

((Me)(Ph)(C₄H₃SCH₂CH₂)P)BH₃

methyl (S)-2-(2-chlorophenyl)-2-[2-(thien-2-yl)ethylamino]acetate

2-[2-(3-methyl-4-nitrophenyl)ethyl]thiophene

Refernces

• 1、 Li, Lixin,Zhao, Zhengguang,Xu, Jing,Luo, Haotian,Li, Yong,Ma, Xiantao,Tang, Lin,Ren, Bo,Cao, Xinhua,Ma, Yan-Na. "Synthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction". supporting information. p. 9384 - 9387. Retrieved 2020/10/02.
• 2、 Martins, Andrew,Lautens, Mark. "A palladium-catalyzed approach to polycyclic sulfur heterocycles". supporting information; experimental part. p. 8705 - 8710. Retrieved 2009/04/11.