3-tosylbutanenitrile

Base Information

• Chemical Name: 3-tosylbutanenitrile
• CAS No.: 99855-23-9
• Molecular Formula: C₁₁H₁₃NO₂S
• Molecular Weight: 223.296
• Mol file: 99855-23-9.mol

Synonyms:3-tosylbutanenitrile

Chemical Property of 3-tosylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-tosylbutanenitrile

There total 3 articles about 3-tosylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

but-2-enenitrile (4786-20-3,627-26-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 3-tosylbutanenitrile (99855-23-9)

Guidance literature:

With water; at 120 ℃; for 10h; Sealed tube; Green chemistry;

DOI:10.1039/c7ob01558e

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 3-tosylbutanenitrile (99855-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran / 0.42 h / 0 °C

2: water / 10 h / 120 °C / Sealed tube; Green chemistry

With water; hydrazine hydrate; In tetrahydrofuran; 2: |Michael Addition;

DOI:10.1039/c7ob01558e

Reference yield:

but-2-enenitrile (4786-20-3,627-26-9) + sodium 4-methylbenzenesulfinate (824-79-3) → 3-tosylbutanenitrile (99855-23-9)

Guidance literature:

With sodium dihydrogenphosphate; water;

upstream raw materials:

but-2-enenitrile

sodium 4-methylbenzenesulfinate

toluene-4-sulfonic acid hydrazide

p-toluenesulfonyl chloride

Refernces