C₂₇H₃₁IN₂O₃

Base Information

• Chemical Name: C₂₇H₃₁IN₂O₃
• CAS No.: 1320267-40-0
• Molecular Formula: C₂₇H₃₁IN₂O₃
• Molecular Weight: 558.459
• Mol file: 1320267-40-0.mol

Synonyms:C₂₇H₃₁IN₂O₃

Chemical Property of C₂₇H₃₁IN₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₂₇H₃₁IN₂O₃

There total 1 articles about C₂₇H₃₁IN₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

phosgene (75-44-5) + (Z)-4-bromo-3-iodobut-2-en-1-yl acetate (1320267-38-6) + C28H30N2O4 (1320267-36-4) → C27H31IN2O3 (1320267-40-0)

Guidance literature:

C₂₈H₃₀N₂O₄; With Wilkinson's catalyst; benzonitrile; In toluene; at 120 ℃;

phosgene; With triethylamine; In toluene; at -45 - 23 ℃;

(Z)-4-bromo-3-iodobut-2-en-1-yl acetate; Further stages;

DOI:10.1038/nature10232

Reference yield: 58.0%

C27H31IN2O3 (1320267-40-0) → C27H30N2O3 (1320267-43-3)

Guidance literature:

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In ethyl acetate; at 23 ℃;

DOI:10.1038/nature10232

Reference yield:

C27H31IN2O3 (1320267-40-0) → strychnidin-10-one (57-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate / ethyl acetate / 23 °C

2: thiophenol; trifluoroacetic acid / 45 °C

3: sodium acetate; acetic anhydride / acetic acid / 120 °C

With tetrabutyl-ammonium chloride; sodium acetate; palladium diacetate; acetic anhydride; sodium hydrogencarbonate; thiophenol; trifluoroacetic acid; In acetic acid; ethyl acetate; 1: Heck reaction;

DOI:10.1038/nature10232

upstream raw materials:

phosgene

(Z)-4-bromo-3-iodobut-2-en-1-yl acetate

C₂₈H₃₀N₂O₄

Downstream raw materials:

C₂₇H₃₀N₂O₃

strychnidin-10-one

Refernces