1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

Base Information Edit

Chemical Name:1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide
CAS No.:1089186-95-7
Molecular Formula:C₁₁H₁₇FNO₂*I
Molecular Weight:341.164
Hs Code.:
Mol file:1089186-95-7.mol

Synonyms:1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

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Chemical Property of 1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide Edit

Chemical Property:

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Technology Process of 1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

There total 3 articles about 1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103905-49-3
5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene

: 74-88-4
methyl iodide

: 1089186-95-7
1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

Guidance literature:: In chloroform; at 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2013.07.042

Reference yield:

: 456-49-5
1-fluoro-3-methoxybenzene

: 1089186-95-7
1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -65 °C

1.2: 1.5 h / -78 °C

1.3: 0 °C

2.1: ethanol / 2 h / Reflux

3.1: chloroform / 20 °C

With n-butyllithium; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1055/s-0034-1379481

Reference yield:

: 73943-41-6
2-fluoro-6-methoxyphenol

: 1089186-95-7
1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 2 h / Reflux

2: chloroform / 18 h / 20 °C

In ethanol; chloroform; 1: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.07.042