JNK Inhibitor II, Negative Control

Base Information

• Chemical Name: JNK Inhibitor II, Negative Control
• CAS No.: 54642-23-8
• Molecular Formula: C₁₅H₁₀N₂O
• Molecular Weight: 234.257
• Mol file: 54642-23-8.mol

Synonyms:JNK Inhibitor II, Negative Control

Chemical Property of JNK Inhibitor II, Negative Control

Chemical Property:

• Storage Temp.: -20C

Purity/Quality:

99% ^*data from raw suppliers

JNK inhibitor II, negative control ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: JNK inhibitor II, negative control is the methylated analog of JNK inhibitor II and exhibits a lower affinity for JNK2 and JNK3. This compound is suitable to be used as a negative control in various kinase assays.

Technology Process of JNK Inhibitor II, Negative Control

There total 10 articles about JNK Inhibitor II, Negative Control which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-fluoro-9,10-anthraquinone (569-06-2) + methylhydrazine (60-34-4) → JNK Inhibitor II, Negative Control (54642-23-8)

Guidance literature:

With pyridine; at 20 ℃; for 19h;

DOI:10.1002/jhet.5570370108

Reference yield: 83.0%

1-chloroanthracene-9,10-dione (82-44-0) + methylhydrazine (60-34-4) → JNK Inhibitor II, Negative Control (54642-23-8)

Guidance literature:

In tetrahydrofuran; N,N-dimethyl acetamide; at 80 ℃; for 16h;

DOI:10.1021/ol062890e

Reference yield: 53.0%

1-fluoro-9,10-anthraquinone (569-06-2) + N,N-Dimethylhydrazine (57-14-7) → 1-(methylamino)anthraquinone (82-38-2) + 1-dimethylaminoanthraquinone (5960-55-4) + 1-(N',N'-Dimethyl-hydrazino)-anthraquinone (117499-94-2) + JNK Inhibitor II, Negative Control (54642-23-8)

Guidance literature:

In pyridine; at 96 ℃; for 48h;

DOI:10.1021/jo00260a022

upstream raw materials:

1,9-pyrazoloanthrone

methyl p-toluene sulfonate

dimethyl sulfate

1-chloroanthracene-9,10-dione

Downstream raw materials:

2,2'-dimethyl-2H,2'H-[3,3']bi[dibenz[cd,g]indazolyl]-6,6'-dione

Refernces

• 1、 Vina, Dolores,Del Olmo, Esther,Lopez-Perez, Jose L.,Feliciano, Arturo San. "Regioselective synthesis of 1-alkyl- Or 1-aryl-1H-indazoles via copper-catalyzed cyclizations of 2-haloarylcarbonylic compounds". . p. 525 - 528. Retrieved 2007/10/03.
• 2、 Krapcho, A. Paul,Avery, Kenneth L.. "Formation of N-N and N-C Bond-Cleavage Products in Displacements with N,N-Disubstituted Hydrazines on 1-Halo- or 1,4-Dihaloanthracene-9,10-diones". . p. 5927 - 5929. Retrieved 2007/10/02.