3,5-DIBROMOSALICYLALDOXIME

Base Information

• Chemical Name: 3,5-DIBROMOSALICYLALDOXIME
• CAS No.: 21386-43-6
• Molecular Formula: C7H5 Br2 N O2
• Molecular Weight: 294.93
• Hs Code.: 2928000090
• Mol file: 21386-43-6.mol

Synonyms:Salicylaldehyde,3,5-dibromo-, oxime (6CI,8CI)

Chemical Property of 3,5-DIBROMOSALICYLALDOXIME

Chemical Property:

• Melting Point: 227 °C
• Refractive Index: 1.661
• Boiling Point: 325.5±42.0 °C(Predicted)
• PKA: 6.98±0.50(Predicted)
• PSA: 52.82000
• Density: 2.09±0.1 g/cm3(Predicted)
• LogP: 2.72530

Purity/Quality:

98% ^*data from raw suppliers

3,5-Dibromosalicylaldoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIBROMOSALICYLALDOXIME

There total 4 articles about 3,5-DIBROMOSALICYLALDOXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,5-Dibromosalicylaldehyde (90-59-5) → (E)-3,5-dibromo-2-hydroxybenzaldehyde oxime (21386-43-6)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo502396u

Reference yield:

3,5-Dibromosalicylaldehyde (90-59-5) → 3,5-Dibromsalicylaldehyd-oxim (21386-43-6)

Guidance literature:

With ethanol; hydroxylamine hydrochloride;

Reference yield:

salicylaldehyde (90-02-8) → (E)-3,5-dibromo-2-hydroxybenzaldehyde oxime (21386-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid / durch Bromierung

2: aqueous-alcoholic NaOH-solution; hydroxylamine hydrochloride / 25 °C

With sodium hydroxide; hydroxylamine hydrochloride; acetic acid;

upstream raw materials:

3,5-Dibromosalicylaldehyde

salicylaldehyde

Downstream raw materials:

3,5-dibromo-2-hydroxybenzonitrile

2-aminomethyl-4,6-dibromo-phenol

Refernces

• 1、 Whiting, Ellis,Lanning, Maryanna E.,Scheenstra, Jacob A.,Fletcher, Steven. "Chromatography-free entry to substituted salicylonitriles: Mitsunobu-triggered domino reactions of salicylaldoximes". . p. 1229 - 1234. Retrieved 2015/01/30.